[HTML][HTML] BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells
MJ van Helden, SA Zwarthoff, RJ Arends… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Preclinical studies have firmly established the CD47-signal-regulatory protein
(SIRP) α axis as a myeloid immune checkpoint in cancer, and this is corroborated by …
(SIRP) α axis as a myeloid immune checkpoint in cancer, and this is corroborated by …
[HTML][HTML] Survival of metastatic melanoma patients after dendritic cell vaccination correlates with expression of leukocyte phosphatidylethanolamine-binding protein 1 …
SI Buschow, M Ramazzotti, IMJ Reinieren-Beeren… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Immunotherapy for metastatic melanoma offers great promise but, to date, only a subset of
patients have responded. There is an urgent need to identify ways of allocating patients to …
patients have responded. There is an urgent need to identify ways of allocating patients to …