[HTML][HTML] Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

R Ravi, KA Noonan, V Pham, R Bedi… - Nature …, 2018 - nature.com
A majority of cancers fail to respond to immunotherapy with antibodies targeting immune
checkpoints, such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) or programmed death-1 …

Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a …

J Bolaños-Meade, KR Cooke, CJ Gamper… - The Lancet …, 2019 - thelancet.com
Background Although severe haemoglobinopathies can be cured with allogeneic blood or
bone marrow transplantation, availability of matched donors and toxic effects can be …

[HTML][HTML] Absence of post-transplantation lymphoproliferative disorder after allogeneic blood or marrow transplantation using post-transplantation cyclophosphamide …

JA Kanakry, YL Kasamon, J Bolaños-Meade… - Biology of Blood and …, 2013 - Elsevier
Immunosuppressive regimens that effectively prevent graft-versus-host disease (GVHD)
after allogeneic blood or marrow transplantation (allo-BMT) have been associated with an …

Granulocyte-macrophage colony-stimulating factor (GM-CSF)–secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as …

IM Borrello, HI Levitsky, W Stock, D Sher… - Blood, The Journal …, 2009 - ashpublications.org
Preclinical models have demonstrated the efficacy of granulocyte-macrophage colony-
stimulating factor-secreting cancer immunotherapies (GVAX platform) accompanied by …

Immunotherapeutic approaches for hematologic malignancies

MA Caligiuri, A Velardi, DA Scheinberg… - ASH Education …, 2004 - ashpublications.org
The immune system has two complementary arms: one is older and seemingly more
primitive, called the innate immune system, found in both plants and animals. The second …

Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study

H El-Khoury, DJ Lee, JB Alberge, R Redd… - The Lancet …, 2022 - thelancet.com
Background Prevalence estimates for monoclonal gammopathy of undetermined
significance (MGUS) are based on predominantly White study populations screened by …

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

CG Kanakry, J Bolaños-Meade… - Blood, The Journal …, 2017 - ashpublications.org
The intensive and prolonged immunosuppressive therapy required to prevent or treat graft-
versus-host disease (GVHD) after allogeneic blood or marrow transplantation (alloBMT) puts …

Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to …

A Cuenca, F Cheng, H Wang, J Brayer, P Horna, L Gu… - Cancer research, 2003 - AACR
A better understanding of how solid malignancies arise in an immunocompetent host, avoid
immune recognition, and ultimately progress to widely disseminated cancer is essential to …

[HTML][HTML] Severe cytokine release syndrome after haploidentical peripheral blood stem cell transplantation

PH Imus, AL Blackford, M Bettinotti, L Luznik… - Biology of Blood and …, 2019 - Elsevier
Inflammatory cytokines released by activated lymphocytes and innate cells in the context of
cellular therapy can cause fever, vasodilatation, and end-organ damage, collectively known …

[HTML][HTML] Major histocompatibility mismatch and donor choice for second allogeneic bone marrow transplantation

PH Imus, AL Blackford, M Bettinotti, B Iglehart… - Biology of Blood and …, 2017 - Elsevier
Large alternative donor pools provide the potential for selecting a different donor for a
second allogeneic (allo) bone or marrow transplant (BMT). As HLA disparity may contribute …