The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration

M Kaucká, K Plevová, Š Pavlová, P Janovská, A Mishra… - Cancer research, 2013 - AACR
The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration
and polarity in various contexts. Here we show that key PCP pathway components such as …

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

M Mraz, D Dolezalova, K Plevova… - Blood, The Journal …, 2012 - ashpublications.org
MicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B
cells. Notably, miRNA gene encoding miR-650 and its homologs overlap with several …

Human embryonic stem cells are capable of executing G1/S checkpoint activation

T Bárta, V Vinarský, Z Holubcová, D Doležalová… - Stem Cells, 2010 - academic.oup.com
Embryonic stem cells progress very rapidly through the cell cycle, allowing limited time for
cell cycle regulatory circuits that typically function in somatic cells. Mechanisms that inhibit …

FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia

V Seda, E Vojackova, L Ondrisova… - Blood, The Journal …, 2021 - ashpublications.org
Recirculation of chronic lymphocytic leukemia (CLL) cells between the peripheral blood and
lymphoid niches plays a critical role in disease pathophysiology, and inhibiting this process …

Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia

P Janovska, J Verner, J Kohoutek… - Blood, The Journal …, 2018 - ashpublications.org
Casein kinase 1δ/ε (CK1δ/ε) is a key component of noncanonical Wnt signaling pathways,
which were shown previously to drive pathogenesis of chronic lymphocytic leukemia (CLL) …

[HTML][HTML] Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro

A Ledererova, L Dostalova, V Kozlova… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Anti-CD19 chimeric antigen receptor T cells (CART-19) frequently induce
remissions in hemato-oncological patients with recurred and/or refractory B-cell tumors …

[HTML][HTML] Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

M Boudny, J Zemanova, P Khirsariya, M Borsky… - …, 2019 - ncbi.nlm.nih.gov
Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein
significantly improves therapeutic options in chronic lymphocytic leukemia. However, some …

Transcription factor c-Myb: novel prognostic factor in osteosarcoma

K Říhová, M Dúcka, IS Zambo, L Vymětalová… - Clinical & Experimental …, 2022 - Springer
The transcription factor c-Myb is an oncoprotein promoting cell proliferation and survival
when aberrantly activated/expressed, thus contributing to malignant transformation …

[HTML][HTML] Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells

J Zemanova, O Hylse, J Collakova, P Vesely, A Oltova… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Treatment options for TP53-mutated lymphoid tumors are very limited. In
experimental models, TP53-mutated lymphomas were sensitive to direct inhibition of …

Preference and area coordination of public transport in modern city

I Hurtova, M Sejkorova, J Verner… - Engineering for Rural …, 2018 - dk.upce.cz
The purpose of the document is to analyse and evaluate the situation in the field of
chronometrations of the town's public transport company Dopravní společnost Zlín …