Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index

LR Desnoyers, O Vasiljeva, JH Richardson… - Science translational …, 2013 - science.org
Target-mediated toxicity constitutes a major limitation for the development of therapeutic
antibodies. To redirect the activity of antibodies recognizing widely distributed targets to the …

[HTML][HTML] CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma

BD Choi, X Yu, AP Castano, H Darr… - … for immunotherapy of …, 2019 - Springer
Despite remarkable success in the treatment of hematological malignancies, CAR T-cell
therapies for solid tumors have floundered, in large part due to local immune suppression …

A leucine-rich repeat region is conserved in pollen extensin-like (Pex) proteins in monocots and dicots

S Stratford, W Barnes, DL Hohorst, JG Sagert… - Plant molecular …, 2001 - Springer
We previously isolated a pollen-specific gene encoding a pollen tube wall-associated
glycoprotein with a globular domain and an extensin domain from maize (mPex1). To …

Cell Biology of Plant and Fungal Tip Growth 171 A. Geitmann et al.(Eds.) IOS Press, 2001

W BARNESą, JG SAGERT, R COTTER… - Cell Biology of Plant …, 2001 - books.google.com
We have identified a family of pollen glycoproteins, called Pex proteins (Pollen extensin-
like). The Pex proteins are extensin chimeras, with a C-terminal domain having numerous …