User profiles for "author:Javier Hernandez-Losa"

Javier Hernandez Losa

Servicio de Anatomia Patologica. Hospital Universitario Vall d´Hebron
Verified email at vhebron.net
Cited by 5121

[HTML][HTML] Clinical implications of intratumor heterogeneity: challenges and opportunities

S Ramón y Cajal, M Sesé, C Capdevila… - Journal of Molecular …, 2020 - Springer
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

[HTML][HTML] The voltage-dependent K+ channels Kv1. 3 and Kv1. 5 in human cancer

N Comes, J Bielanska, A Vallejo-Gracia… - Frontiers in …, 2013 - frontiersin.org
Voltage-dependent K+ channels (Kv) are involved in a number of physiological processes,
including immunomodulation, cell volume regulation, apoptosis as well as differentiation …

[HTML][HTML] Regulation of the transcriptional activity of c-Fos by ERK: a novel role for the prolyl isomerase PIN1

P Monje, J Hernández-Losa, RJ Lyons… - Journal of Biological …, 2005 - ASBMB
The activation of the activating protein-1 (AP-1) family of transcription factors, including c-Fos
and c-Jun family members, is one of the earliest nuclear events induced by growth factors …

[HTML][HTML] Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM

JG Viniegra, N Martínez, P Modirassari, JH Losa… - Journal of Biological …, 2005 - ASBMB
The gene mutated in ataxia telangiectasia, ATM, has been implicated in several cell
functions such as cell cycle control and response to DNA damage and insulin. PKB/Akt has …

[HTML][HTML] Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform …

FH Blackhall, S Peters, L Bubendorf, U Dafni… - Journal of clinical …, 2014 - sonar.ch
The prevalence of anaplastic lymphoma kinase (ALK) gene fusion (ALK positivity) in early-
stage non-small-cell lung cancer (NSCLC) varies by population examined and detection …

[HTML][HTML] miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9

A Feliciano, J Castellvi, A Artero-Castro, JA Leal… - PloS one, 2013 - journals.plos.org
MicroRNAs (miRNAs) play important roles in diverse biological processes and are emerging
as key regulators of tumorigenesis and tumor progression. To explore the dysregulation of …

Role of the p38 MAPK pathway in cisplatin-based therapy

JH Losa, CP Cobo, JG Viniegra, VJSA Lobo… - Oncogene, 2003 - nature.com
Abstract p38 MAPK has been implicated in the response to cancer therapy. To determine
whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the …

[HTML][HTML] RHOA inactivation enhances Wnt signalling and promotes colorectal cancer

P Rodrigues, I Macaya, S Bazzocco, R Mazzolini… - Nature …, 2014 - nature.com
Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types,
although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation …

[HTML][HTML] Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise

M Garrido-Pontnou, A Navarro, J Camacho, F Crispi… - Modern Pathology, 2021 - Elsevier
Placental pathology in SARS-CoV-2-infected pregnancies seems rather unspecific.
However, the identification of the placental lesions due to SARS-CoV-2 infection would be a …

[HTML][HTML] miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer

A Feliciano, Y Garcia-Mayea, L Jubierre, C Mir… - Cell death & …, 2017 - nature.com
Lung cancer is one of the most aggressive tumours with very low life expectancy. Altered
microRNA expression is found in human tumours because it is involved in tumour growth …