User profiles for "author:Javier Hernandez-Losa"
Javier Hernandez LosaServicio de Anatomia Patologica. Hospital Universitario Vall d´Hebron Verified email at vhebron.net Cited by 5121 |
[HTML][HTML] Clinical implications of intratumor heterogeneity: challenges and opportunities
S Ramón y Cajal, M Sesé, C Capdevila… - Journal of Molecular …, 2020 - Springer
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …
[HTML][HTML] The voltage-dependent K+ channels Kv1. 3 and Kv1. 5 in human cancer
N Comes, J Bielanska, A Vallejo-Gracia… - Frontiers in …, 2013 - frontiersin.org
Voltage-dependent K+ channels (Kv) are involved in a number of physiological processes,
including immunomodulation, cell volume regulation, apoptosis as well as differentiation …
including immunomodulation, cell volume regulation, apoptosis as well as differentiation …
[HTML][HTML] Regulation of the transcriptional activity of c-Fos by ERK: a novel role for the prolyl isomerase PIN1
P Monje, J Hernández-Losa, RJ Lyons… - Journal of Biological …, 2005 - ASBMB
The activation of the activating protein-1 (AP-1) family of transcription factors, including c-Fos
and c-Jun family members, is one of the earliest nuclear events induced by growth factors …
and c-Jun family members, is one of the earliest nuclear events induced by growth factors …
[HTML][HTML] Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
JG Viniegra, N Martínez, P Modirassari, JH Losa… - Journal of Biological …, 2005 - ASBMB
The gene mutated in ataxia telangiectasia, ATM, has been implicated in several cell
functions such as cell cycle control and response to DNA damage and insulin. PKB/Akt has …
functions such as cell cycle control and response to DNA damage and insulin. PKB/Akt has …
[HTML][HTML] Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform …
The prevalence of anaplastic lymphoma kinase (ALK) gene fusion (ALK positivity) in early-
stage non-small-cell lung cancer (NSCLC) varies by population examined and detection …
stage non-small-cell lung cancer (NSCLC) varies by population examined and detection …
[HTML][HTML] miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9
A Feliciano, J Castellvi, A Artero-Castro, JA Leal… - PloS one, 2013 - journals.plos.org
MicroRNAs (miRNAs) play important roles in diverse biological processes and are emerging
as key regulators of tumorigenesis and tumor progression. To explore the dysregulation of …
as key regulators of tumorigenesis and tumor progression. To explore the dysregulation of …
Role of the p38 MAPK pathway in cisplatin-based therapy
Abstract p38 MAPK has been implicated in the response to cancer therapy. To determine
whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the …
whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the …
[HTML][HTML] RHOA inactivation enhances Wnt signalling and promotes colorectal cancer
P Rodrigues, I Macaya, S Bazzocco, R Mazzolini… - Nature …, 2014 - nature.com
Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types,
although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation …
although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation …
[HTML][HTML] Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise
M Garrido-Pontnou, A Navarro, J Camacho, F Crispi… - Modern Pathology, 2021 - Elsevier
Placental pathology in SARS-CoV-2-infected pregnancies seems rather unspecific.
However, the identification of the placental lesions due to SARS-CoV-2 infection would be a …
However, the identification of the placental lesions due to SARS-CoV-2 infection would be a …
[HTML][HTML] miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer
A Feliciano, Y Garcia-Mayea, L Jubierre, C Mir… - Cell death & …, 2017 - nature.com
Lung cancer is one of the most aggressive tumours with very low life expectancy. Altered
microRNA expression is found in human tumours because it is involved in tumour growth …
microRNA expression is found in human tumours because it is involved in tumour growth …