A DNA-based vaccine containing human immunodeficiency virus type 1 (HIV-1) env and rev
genes was tested for safety and host immune response in 15 asymptomatic HIV-infected …

Background A vaccine against SARS-CoV-2 is of high urgency. Here the safety and
immunogenicity induced by a DNA vaccine (INO-4800) targeting the full length spike antigen …

Despite the development of highly effective prophylactic vaccines against human
papillomavirus (HPV) serotypes 16 and 18, prevention of cervical dysplasia and cancer in …

Genetic immunization, also known as DNA or polynucleotide immunization, is a novel
strategy for vaccine development in which plasmid DNA encoding either individual or a …

Novel approaches for the generation of more effective vaccines for HIV-1 are of significant
importance. In this report we analyze the immunogenicity and efficacy of an HIV-1 DNA …

Recent studies support the importance of investigating a DNA vaccination approach for the
immunologic control of HIV-1. In this regard, it may be important to specifically engineer …

Animal models are of great importance for the study of disease pathogenesis, particularly
non-human-primate models of infectious diseases. The role of non-human primates in HIV-1 …

About 25% of high-grade cervical intraepithelial neoplasias (CIN2/3) caused by human
papillomavirus serotype 16 (HPV16) undergo complete spontaneous regression. However …

The potential roles of CD8 (+) T-cell-induced chemokines in the expansion of immune
responses were examined using DNA immunogen constructs as model antigens. We …

DNA vaccines are a promising technology for the induction of Ag-specific immune
responses, and much recent attention has gone into improving their immune potency. In this …