Although Th17 cells are known to promote tissue inflammation and autoimmunity, their role
during cancer progression remains elusive. Here, we showed that in vitro Th17 cells …

Immunological tolerance is maintained by specialized subsets of T cells including CD4+
CD25+ FOXP3+ regulatory cells (Treg). Previous studies established that Treg thymic …

Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased
capacities of proliferation, invasion and have the ability to generate metastases by escaping …

The role of natural killer group 2, member D receptor (NKG2D)–expressing natural killer
(NK) cells in tumor immunosurveillance is now well established. Nevertheless, tumor …

Human CD20 is a B-cell lineage–specific marker expressed by normal and leukemic B cells
from the pre-B to the plasma-cell stages and is a target for rituximab (RTX) immunotherapy …

The rapalogs everolimus and temsirolimus that inhibit mTOR signaling are used as
antiproliferative drugs in several cancers. Here we investigated the influence of rapalogs …

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is associated with a remarkably poor
prognosis and with no treatment consensus. The identification of relevant therapeutic targets …

Background Multiple synergistic combination approaches with cancer drugs are developed
to overcome primary resistance to immunotherapy; however, the mechanistic rationale to …

Combining immunogenic cell death-inducing chemotherapies and PD-1 blockade can
generate remarkable tumor responses. It is now well established that TGF-β1 signaling is a …

NK cells are critical for innate immunity–mediated protection. The main roles of NK cells rely
on their cytotoxic functions or depend on the tuning of Th1 adaptive immunity by IFN-γ …