[HTML][HTML] Translational genomics of nasopharyngeal cancer
Nasopharyngeal carcinoma (NPC), also named the Cantonese cancer, is a unique cancer
with strong etiological association with infection of the Epstein-Barr virus (EBV). With …
with strong etiological association with infection of the Epstein-Barr virus (EBV). With …
[PDF][PDF] Colorectal cancer cells enter a diapause-like DTP state to survive chemotherapy
Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from
chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important …
chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important …
[HTML][HTML] Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab …
SY Cindy Yang, SC Lien, BX Wang… - Nature …, 2021 - nature.com
Serial circulating tumor DNA (ctDNA) monitoring is emerging as a non-invasive strategy to
predict and monitor immune checkpoint blockade (ICB) therapeutic efficacy across cancer …
predict and monitor immune checkpoint blockade (ICB) therapeutic efficacy across cancer …
Adavosertib plus gemcitabine for platinum-resistant or platinum-refractory recurrent ovarian cancer: a double-blind, randomised, placebo-controlled, phase 2 trial
Summary Background The Wee1 (WEE1hu) inhibitor adavosertib and gemcitabine have
shown preclinical synergy and promising activity in early phase clinical trials. We aimed to …
shown preclinical synergy and promising activity in early phase clinical trials. We aimed to …
The genomic landscape of schwannoma
Schwannomas are common peripheral nerve sheath tumors that can cause debilitating
morbidities. We performed an integrative analysis to determine genomic aberrations …
morbidities. We performed an integrative analysis to determine genomic aberrations …
Human papillomavirus genotype association with survival in head and neck squamous cell carcinoma
Discussion| Our investigation shows that the use of Twitter for support (28%) and prevention
(28%) dialogues is common. Although some tweets are about clinical trials (18%), virtually …
(28%) dialogues is common. Although some tweets are about clinical trials (18%), virtually …
EVOLVE: a multicenter open-label single-arm clinical and translational phase II trial of cediranib plus olaparib for ovarian cancer after PARP inhibition progression
Purpose: PARP inhibitors (PARPi) are standard-of-care therapy for high-grade serous
ovarian cancer (HGSOC). We investigated combining cediranib (antiangiogenic) with …
ovarian cancer (HGSOC). We investigated combining cediranib (antiangiogenic) with …
[PDF][PDF] Patient-derived xenografts for prognostication and personalized treatment for head and neck squamous cell carcinoma
C Karamboulas, JP Bruce, AJ Hope, J Meens… - Cell reports, 2018 - cell.com
Overall survival remains very poor for patients diagnosed as having head and neck
squamous cell carcinoma (HNSCC). Identification of additional biomarkers and novel …
squamous cell carcinoma (HNSCC). Identification of additional biomarkers and novel …
[HTML][HTML] Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study
Background Sitravatinib, a tyrosine kinase inhibitor that targets TYRO3, AXL, MERTK and
the VEGF receptor family, is predicted to increase the M1 to M2-polarized tumor-associated …
the VEGF receptor family, is predicted to increase the M1 to M2-polarized tumor-associated …
[HTML][HTML] A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene
Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the
BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination …
BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination …