In the central nervous system (CNS), Src and other Src family kinases are widely expressed
and are abundant in neurons. Src has been implicated in proliferation and differentiation …

Background The effectiveness of surgery versus observation for men with localized prostate
cancer detected by means of prostate-specific antigen (PSA) testing is not known. Methods …

We have previously reported the development of a transgenic mouse model for prostate
cancer derived from PB-Tag transgenic line 8247, henceforth designated the TRAMP …

To develop a syngeneic transplantable system to study immunotherapeutic approaches for
the treatment of prostate cancer, three cell lines were established from a heterogeneous 32 …

We previously established the autochthonous transgenic adenocarcinoma mouse prostate
(TRAMP) model to facilitate characterization of molecular mechanisms involved in the …

Chronic pain hypersensitivity depends on N-methyl-d-aspartate receptors (NMDARs).
However, clinical use of NMDAR blockers is limited by side effects resulting from …

Purpose The activity of the novel antitumor agent tasquinimod (TASQ) with S100A9 as a
molecular target was investigated in men with metastatic castration-resistant prostate cancer …

▪ Abstract Gene function during mammalian development is often studied by making
irreversible changes to the genome. This approach has a major drawback in that the …

BACKGROUND: Prostate cancer is the most common noncutaneous malignancy and the
second leading cause of cancer death in men. Ninety percent of men with prostate cancer …

Src is the prototypic protein tyrosine kinase and is critical for controlling diverse cellular
functions. Regions in Src define structural and functional domains conserved in many cell …