Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 …
Purpose: Triple-negative breast cancer (TNBC) is an aggressive disease with limited
therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 …
therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 …
[HTML][HTML] 799 Durable responses and immune activation with intratumoral electroporation of pIL-12 plus pembrolizumab in actively progressing anti-PD-1 refractory …
Background Electroporated plasmid IL-12 (TAVO or tavokinogene telseplasmid) is a novel
pro-inflammatory intratumoral therapy with substantial single agent activity in melanoma …
pro-inflammatory intratumoral therapy with substantial single agent activity in melanoma …
[HTML][HTML] 383 Durable responses with intratumoral electroporation of plasmid interleukin 12 plus pembrolizumab in patients with advanced melanoma progressing on …
Background Electroporated plasmid interleukin-12 (pIL-12-EP; tavokinogene telseplasmid;
TAVO) induces sustained intratumoral expression of IL-12, a cytokine that is integral for …
TAVO) induces sustained intratumoral expression of IL-12, a cytokine that is integral for …
Intratumoral Plasmid IL12 Expands CD8
PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive disease with limited
therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 …
therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 …