Veterinary cooperative oncology group—common terminology criteria for adverse events (VCOG‐CTCAE v2) following investigational therapy in dogs and cats

AK LeBlanc, M Atherton, RT Bentley… - Veterinary and …, 2021 - Wiley Online Library
The updated VCOG‐CTCAE v2 guidelines contain several important updates and additions
since the last update (v1. 1) was released in 2011 and published within Veterinary and …

Adjuvant sirolimus does not improve outcome in pet dogs receiving standard-of-care therapy for appendicular osteosarcoma: a prospective, randomized trial of 324 …

AK LeBlanc, CN Mazcko, A Cherukuri, EP Berger… - Clinical Cancer …, 2021 - AACR
Purpose: The mTOR pathway has been identified as a key nutrient signaling hub that
participates in metastatic progression of high-grade osteosarcoma. Inhibition of mTOR …

[HTML][HTML] Association of cancer-related mortality, age and gonadectomy in golden retriever dogs at a veterinary academic center (1989-2016)

MS Kent, JH Burton, G Dank, DL Bannasch… - PloS one, 2018 - journals.plos.org
Golden retriever dogs have been reported to have an increased prevalence of cancer
compared to other breeds. There is also controversy over the effect spay or neuter status …

NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma

JH Burton, C Mazcko, A LeBlanc, JM Covey, J Ji… - Clinical Cancer …, 2018 - AACR
Purpose: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the
camptothecins with irinotecan and topotecan widely used. Because of their limitations …

[HTML][HTML] Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity …

RB Rebhun, D York, SM Cruz, SJ Judge… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Purpose Although recombinant human interleukin-15 (rhIL-15) has generated much
excitement as an immunotherapeutic agent for cancer, activity in human clinical trials has …

Association of surgical approach with complication rate, progression-free survival time, and disease-specific survival time in cats with mammary adenocarcinoma: 107 …

F Gemignani, PD Mayhew, MA Giuffrida… - Journal of the …, 2018 - Am Vet Med Assoc
OBJECTIVE To evaluate potential associations between surgical approach and
complication rate, progression-free survival time, and disease-specific survival time in cats …

Lower urinary tract transitional cell carcinoma in cats: Clinical findings, treatments, and outcomes in 118 cases

MA Griffin, WTN Culp, MA Giuffrida… - Journal of veterinary …, 2020 - Wiley Online Library
Background Lower urinary tract transitional cell carcinoma (TCC) is an important but rarely
described disease of cats. Objectives To report the clinical characteristics, treatments, and …

Patient characteristics, prognostic factors and outcome of dogs with high‐grade primary mediastinal lymphoma

EL Moore, W Vernau, RB Rebhun… - Veterinary and …, 2018 - Wiley Online Library
The goals of this retrospective study were to determine the patient characteristics of dogs
with high‐grade primary mediastinal lymphoma and to determine outcome and associated …

[HTML][HTML] A comparative oncology study of iniparib defines its pharmacokinetic profile and biological activity in a naturally-occurring canine cancer model

C Saba, M Paoloni, C Mazcko, W Kisseberth… - PLoS …, 2016 - journals.plos.org
Development of iniparib as an anti-cancer agent was hindered in part by lingering questions
regarding its mechanism of action, the activity of its metabolites, and their potential …

In vitro and in vivo activity of liposome‐encapsulated curcumin for naturally occurring canine cancers

SS Withers, D York, E Johnson… - Veterinary and …, 2018 - Wiley Online Library
Curcumin has well‐established anti‐cancer properties in vitro, however, its therapeutic
potential has been hindered by its poor bioavailability. Lipocurc is a proprietary liposome …