CD40L is transferred to antigen‐presenting B cells during delivery of T‐cell help

JL Gardell, DC Parker - European journal of immunology, 2017 - Wiley Online Library
The delivery of T‐cell help to B cells is antigen‐specific, MHC‐restricted, and CD40L
(CD154) dependent. It has been thought that when a T cell recognizes an antigen …

[HTML][HTML] Human macrophages engineered to secrete a bispecific T cell engager support antigen-dependent T cell responses to glioblastoma

JL Gardell, LR Matsumoto, H Chinn… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Targeted and effective treatment options are needed for solid tumors, including
glioblastoma (GBM), where survival rates with standard treatments are typically less than 2 …

[HTML][HTML] Preformed CD40L Is Stored in Th1, Th2, Th17, and T Follicular Helper Cells as Well as CD4+8 Thymocytes and Invariant NKT Cells but Not in Treg Cells

Y Koguchi, AC Buenafe, TJ Thauland, JL Gardell… - PloS one, 2012 - journals.plos.org
CD40L is essential for the development of adaptive immune responses. It is generally
thought that CD40L expression in CD4+ T cells is regulated transcriptionally and made from …

Apoptotic effects of Human Herpesvirus-6A on glia and neurons as potential triggers for central nervous system autoimmunity

JL Gardell, P Dazin, J Islar, T Menge, CP Genain… - Journal of clinical …, 2006 - Elsevier
BACKGROUND: Human Herpesvirus type 6 (HHV-6A and/or HHV-6B) has been tentatively
associated with multiple sclerosis (MS). However, there is currently no direct proof of …

[HTML][HTML] Hypoxia-inducible lentiviral gene expression in engineered human macrophages

HK Chinn, JL Gardell, LR Matsumoto… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Human immune cells, including monocyte-derived macrophages, can be
engineered to deliver proinflammatory cytokines, bispecific antibodies, and chimeric antigen …

[PDF][PDF] Directed delivery of CD40 ligand from helper T cells to antigen-presenting B cells

JL Gardell - 2015 - digitalcollections.ohsu.edu
This dissertation presents my studies investigating the delivery of CD40 ligand (CD40L,
CD154) from helper T lymphocytes to antigen-presenting B lymphocytes. CD40L is a type …

Arming immune cell therapeutics with polymeric prodrugs

CL López, KJ Brempelis, JF Matthaei… - Advanced …, 2022 - Wiley Online Library
Engineered immune cells are an exciting therapeutic modality, which survey and attack
tumors. Backpacking strategies exploit cell targeting capabilities for delivery of drugs to …

[HTML][HTML] Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells

JL Gardell, DC Parker - PLoS One, 2017 - journals.plos.org
Upon recognition of peptide displayed on MHC molecules, Th1 and Th2 cells form distinct
immunological synapse structures. Th1 cells have a bull's eye synapse structure with …

Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro

Y Koguchi, JL Gardell, TJ Thauland… - The Journal of …, 2011 - journals.aai.org
CD40L is critically important for the initiation and maintenance of adaptive immune
responses. It is generally thought that CD40L expression in CD4+ T cells is regulated …

[HTML][HTML] Antigen-specific transfer of CD40L to antigen-presenting B cells during T cell help

JL Gardell, DC Parker - European journal of immunology, 2017 - ncbi.nlm.nih.gov
It has been known for decades that the delivery of T cell help to B cells is antigen-specific,
MHC-restricted, and depends CD40L (CD154). It has been thought that when a T cell …