Theoretical aspects and practical considerations of lubrication in tablet compression are
reviewed in this paper. Properties of the materials that are often used as lubricants, such as …

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies targeting immune checkpoint
molecules. ICIs are an immunotherapy for the treatment of many advanced malignancies …

Background & Aims Magnetic resonance imaging proton density fat fraction (MRI-PDFF)
offers promise as a non-invasive biomarker of treatment response in early-phase …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …

Introduction In vivo imaging provides a window into the spatially complex, rapidly evolving
physiology of the cell that structural imaging alone cannot. However, observing this …

Abstract IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis
because drugs targeting either cytokine are highly effective treatments for this disease. The …

One of the great challenges in science and engineering today is to develop technologies to
improve the health of people in the poorest regions of the world. Here we integrated new …

Single-cell transcriptomic analysis is widely used to study human tumors. However, it
remains challenging to distinguish normal cell types in the tumor microenvironment from …

Human neonates infected with herpes simplex virus 1 (HSV-1) develop one of three distinct
patterns of infection:(i) infection limited to the skin, eye or mouth;(ii) infection of the CNS; or …

Background Few options for transplantation currently exist for patients highly sensitized to
HLA. This exploratory, open-label, phase 1–2, single-center study examined whether …