Murine syngeneic tumor models are critical to novel immuno-based therapy development,
but the molecular and immunologic features of these models are still not clearly defined. The …

Human cytomegalovirus inhibits peptide import into the endoplasmic reticulum (ER) by the
MHC-encoded TAP peptide transporter. We identified the open reading frame US6 to …

Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the
endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to …

The major histocompatibility complex (MHC)‐encoded transporters associated with antigen
processing (TAP) translocate peptides from the cytosol into the lumen of the endoplasmic …

MHC class I molecules present antigenic peptides that are mostly derived from endogenous
cytosolic proteins. Recent studies addressing the function of the proteasome and its activator …

Background T-cell checkpoint blockade and MEK inhibitor combinations are under clinical
investigation. Despite progress elucidating the immuno-modulatory effects of MEK inhibitors …

Resistance to antibody–drug conjugates (ADCs) has been observed in both preclinical
models and clinical studies. However, mechanisms of resistance to pyrrolobenzodiazepine …

The major histocompatibility complex (MHC)‐encoded transporter associated with antigen
processing (TAP) translocates peptides from the cytosol into the lumen of the endoplasmic …

Abstract A recombinant Newcastle Disease Virus (NDV), encoding either a human
(NDVhuGM-CSF, MEDI5395) or murine (NDVmuGM-CSF) GM-CSF transgene, combined …

A surface for the capture of biotin‐tagged proteins on matrix‐assisted laser
desorption/ionisation (MALDI) targets has been investigated. Binding of a poly‐l‐lysine poly …