User profiles for "author:Jessica Roelands"

Jessica Roelands

Leiden University Medical Center
Verified email at lumc.nl
Cited by 1164

[HTML][HTML] NY-ESO-1 based immunotherapy of cancer: current perspectives

R Thomas, G Al-Khadairi, J Roelands… - Frontiers in …, 2018 - frontiersin.org
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-
testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit …

[HTML][HTML] Immunogenomic classification of colorectal cancer and therapeutic implications

J Roelands, PJK Kuppen, L Vermeulen… - International journal of …, 2017 - mdpi.com
The immune system has a substantial effect on colorectal cancer (CRC) progression.
Additionally, the response to immunotherapeutics and conventional treatment options (eg …

[HTML][HTML] HLA-G: a new immune checkpoint in cancer?

D Krijgsman, J Roelands, W Hendrickx… - International journal of …, 2020 - mdpi.com
Human leukocyte antigen G (HLA-G), known as a central protein in providing immune
tolerance to the fetus in pregnant women, is also studied for a possible role in tumor …

[PDF][PDF] Germline genetic contribution to the immune landscape of cancer

RW Sayaman, M Saad, V Thorsson, D Hu, W Hendrickx… - Immunity, 2021 - cell.com
Understanding the contribution of the host's genetic background to cancer immunity may
lead to improved stratification for immunotherapy and to the identification of novel …

[HTML][HTML] Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response

J Roelands, W Hendrickx, G Zoppoli… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background An immune active cancer phenotype typified by a T helper 1 (Th-1) immune
response has been associated with increased responsiveness to immunotherapy and …

Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

J Roelands, M Van der Ploeg, ME Ijsselsteijn, H Dang… - Gut, 2023 - gut.bmj.com
Objective Biological insights into the stepwise development and progression of colorectal
cancer (CRC) are imperative to develop tailored approaches for early detection and optimal …

[HTML][HTML] The immune landscape of solid pediatric tumors

S Sherif, J Roelands, W Mifsud, EI Ahmed… - Journal of Experimental …, 2022 - Springer
Background Large immunogenomic analyses have demonstrated the prognostic role of the
functional orientation of the tumor microenvironment in adult solid tumors, this variable has …

Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data

M Toufiq, J Roelands, M Alfaki… - …, 2020 - Wiley Online Library
According to publicly available transcriptome datasets, the abundance of Annexin A3
(ANXA3) is robustly increased during the course of sepsis; however, no studies have …

The MAPK hypothesis: immune-regulatory effects of MAPK-pathway genetic dysregulations and implications for breast cancer immunotherapy

D Bedognetti, J Roelands, J Decock… - Emerging Topics in …, 2017 - portlandpress.com
With the advent of checkpoint inhibition, immunotherapy has revolutionized the clinical
management of several cancers, but has demonstrated limited efficacy in mammary …

BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R

D Rinchai, J Roelands, M Toufiq, W Hendrickx… - …, 2021 - academic.oup.com
Motivation We previously described the construction and characterization of fixed reusable
blood transcriptional module repertoires. More recently we released a third iteration …