Biomimetic particles as therapeutics
In recent years, there have been major advances in the development of novel nanoparticle-
and microparticle-based therapeutics. An emerging paradigm is the incorporation of …
and microparticle-based therapeutics. An emerging paradigm is the incorporation of …
[HTML][HTML] PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma
Background Merkel-cell carcinoma is an aggressive skin cancer that is linked to exposure to
ultraviolet light and the Merkel-cell polyomavirus (MCPyV). Advanced Merkel-cell carcinoma …
ultraviolet light and the Merkel-cell polyomavirus (MCPyV). Advanced Merkel-cell carcinoma …
Nanoengineering approaches to the design of artificial antigen-presenting cells
JC Sunshine, JJ Green - Nanomedicine, 2013 - Future Medicine
Artificial antigen-presenting cells (aAPCs) have shown great initial promise for ex vivo
activation of cytotoxic T cells. The development of aAPCs has focused mainly on the choice …
activation of cytotoxic T cells. The development of aAPCs has focused mainly on the choice …
Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis
Introduction: Angiogenesis is essential to human biology and of great clinical significance.
Excessive or reduced angiogenesis can result in, or exacerbate, several disease states …
Excessive or reduced angiogenesis can result in, or exacerbate, several disease states …
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade
S Berry, NA Giraldo, BF Green, TR Cottrell, JE Stein… - Science, 2021 - science.org
INTRODUCTION New therapies have been designed to stimulate the host's immune system
to fight cancer. Despite these exciting, recent successes, a large proportion of patients still …
to fight cancer. Despite these exciting, recent successes, a large proportion of patients still …
Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells
Previous work developing particle-based acellular, artificial antigen presenting cells
(aAPCs) has focused exclusively on spherical platforms. To explore the role of shape, we …
(aAPCs) has focused exclusively on spherical platforms. To explore the role of shape, we …
Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy
Therapeutic cancer vaccines require adjuvants leading to robust type I interferon and
proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor …
proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor …
[HTML][HTML] Biodegradable nanoellipsoidal artificial antigen presenting cells for antigen specific T-cell activation
Biomimetic artificial antigen presenting cells (aAPCs) have shown substantial promise as a
platform for immune system activation and modulation. Antigen specific aAPCs reconstitute …
platform for immune system activation and modulation. Antigen specific aAPCs reconstitute …
[HTML][HTML] Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab
NA Giraldo, P Nguyen, EL Engle, GJ Kaunitz… - … for immunotherapy of …, 2018 - Springer
Background We recently reported a 56% objective response rate in patients with advanced
Merkel cell carcinoma (MCC) receiving pembrolizumab. However, a biomarker predicting …
Merkel cell carcinoma (MCC) receiving pembrolizumab. However, a biomarker predicting …
Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical …
JC Sunshine, DY Peng, JJ Green - Molecular pharmaceutics, 2012 - ACS Publications
Development of nonviral particles for gene delivery requires a greater understanding of the
properties that enable gene delivery particles to overcome the numerous barriers to …
properties that enable gene delivery particles to overcome the numerous barriers to …