Peptide length determines the outcome of TCR/peptide-MHCI engagement
J Ekeruche-Makinde, JJ Miles… - Blood, The Journal …, 2013 - ashpublications.org
Abstract αβ-TCRs expressed at the CD8+ T-cell surface interact with short peptide fragments
(p) bound to MHC class I molecules (pMHCI). The TCR/pMHCI interaction is pivotal in all …
(p) bound to MHC class I molecules (pMHCI). The TCR/pMHCI interaction is pivotal in all …
Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells
Fluorochrome-conjugated peptide–major histocompatibility complex (pMHC) multimers are
widely used for flow cytometric visualization of antigen-specific T cells. The most common …
widely used for flow cytometric visualization of antigen-specific T cells. The most common …
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses
A Chancellor, R Alan Simmons, RC Khanolkar… - Journal of Experimental …, 2023 - rupress.org
Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors
(TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting …
(TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting …
[HTML][HTML] Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA
CJ Holland, RM Crean, JM Pentier… - The Journal of …, 2020 - Am Soc Clin Investig
Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the
largest pool of cell surface–expressed cancer-specific epitopes, making them attractive …
largest pool of cell surface–expressed cancer-specific epitopes, making them attractive …
[HTML][HTML] T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
Altered peptide antigens that enhance T-cell immunogenicity have been used to improve
peptide-based vaccination for a range of diseases. Although this strategy can prime T-cell …
peptide-based vaccination for a range of diseases. Although this strategy can prime T-cell …
Naive CD8+ T‐cell precursors display structured TCR repertoires and composite antigen‐driven selection dynamics
Basic parameters of the naive antigen (Ag)‐specific T‐cell repertoire in humans remain
poorly defined. Systematic characterization of this 'ground state'immunity in comparison with …
poorly defined. Systematic characterization of this 'ground state'immunity in comparison with …
[HTML][HTML] Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry
JJ Miles, MP Tan, G Dolton… - The Journal of …, 2018 - Am Soc Clin Investig
Polypeptide vaccines effectively activate human T cells but suffer from poor biological
stability, which confines both transport logistics and in vivo therapeutic activity. Synthetic …
stability, which confines both transport logistics and in vivo therapeutic activity. Synthetic …
[HTML][HTML] Advances in T-cell epitope engineering
T-cells recognize small peptide fragments (p) cradled in multiple major histocompatibility
complex (MHC) molecules, termed human leukocyte antigens (HLA) in humans. These …
complex (MHC) molecules, termed human leukocyte antigens (HLA) in humans. These …
[HTML][HTML] 1349 TROCEPT mediated in-tumor delivery of immune checkpoint inhibitors reduces systemic toxicity risks and boosts immune activation
Background Immune checkpoint inhibitors (ICIs) have revolutionized immunotherapy, but
their efficacy is limited to certain cancers, and response rates are largely dependent on the …
their efficacy is limited to certain cancers, and response rates are largely dependent on the …
897-C TROCEPT tumor-specific targeting and replication enables in-tumor production of immune checkpoint inhibitors following intravenous delivery
RC Khanolkar, JA Davies, AT Baker, TA Webb… - 2023 - jitc.bmj.com
Background TROCEPT is a novel tumor-selective oncolytic adenovirus type 5 engineered to
remove all natural tissue tropisms. This engineering addresses the main limitation of other …
remove all natural tissue tropisms. This engineering addresses the main limitation of other …