Peptide length determines the outcome of TCR/peptide-MHCI engagement

J Ekeruche-Makinde, JJ Miles… - Blood, The Journal …, 2013 - ashpublications.org
Abstract αβ-TCRs expressed at the CD8+ T-cell surface interact with short peptide fragments
(p) bound to MHC class I molecules (pMHCI). The TCR/pMHCI interaction is pivotal in all …

Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

G Dolton, A Lissina, A Skowera, K Ladell… - Clinical & …, 2014 - academic.oup.com
Fluorochrome-conjugated peptide–major histocompatibility complex (pMHC) multimers are
widely used for flow cytometric visualization of antigen-specific T cells. The most common …

Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses

A Chancellor, R Alan Simmons, RC Khanolkar… - Journal of Experimental …, 2023 - rupress.org
Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors
(TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting …

[HTML][HTML] Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA

CJ Holland, RM Crean, JM Pentier… - The Journal of …, 2020 - Am Soc Clin Investig
Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the
largest pool of cell surface–expressed cancer-specific epitopes, making them attractive …

[HTML][HTML] T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting

J Ekeruche-Makinde, M Clement, DK Cole… - Journal of Biological …, 2012 - ASBMB
Altered peptide antigens that enhance T-cell immunogenicity have been used to improve
peptide-based vaccination for a range of diseases. Although this strategy can prime T-cell …

Naive CD8+ T‐cell precursors display structured TCR repertoires and composite antigen‐driven selection dynamics

MA Neller, K Ladell, JE McLaren… - Immunology and cell …, 2015 - Wiley Online Library
Basic parameters of the naive antigen (Ag)‐specific T‐cell repertoire in humans remain
poorly defined. Systematic characterization of this 'ground state'immunity in comparison with …

[HTML][HTML] Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry

JJ Miles, MP Tan, G Dolton… - The Journal of …, 2018 - Am Soc Clin Investig
Polypeptide vaccines effectively activate human T cells but suffer from poor biological
stability, which confines both transport logistics and in vivo therapeutic activity. Synthetic …

[HTML][HTML] Advances in T-cell epitope engineering

J Pentier, A Sewell, JJ Miles - Frontiers in immunology, 2013 - frontiersin.org
T-cells recognize small peptide fragments (p) cradled in multiple major histocompatibility
complex (MHC) molecules, termed human leukocyte antigens (HLA) in humans. These …

[HTML][HTML] 1349 TROCEPT mediated in-tumor delivery of immune checkpoint inhibitors reduces systemic toxicity risks and boosts immune activation

D Cole, R Khanolkar, J Davies, A Baker, T Webb… - 2022 - jitc.bmj.com
Background Immune checkpoint inhibitors (ICIs) have revolutionized immunotherapy, but
their efficacy is limited to certain cancers, and response rates are largely dependent on the …

897-C TROCEPT tumor-specific targeting and replication enables in-tumor production of immune checkpoint inhibitors following intravenous delivery

RC Khanolkar, JA Davies, AT Baker, TA Webb… - 2023 - jitc.bmj.com
Background TROCEPT is a novel tumor-selective oncolytic adenovirus type 5 engineered to
remove all natural tissue tropisms. This engineering addresses the main limitation of other …