Effective clearance of apoptotic cells by macrophages is essential for immune homeostasis.
The transcriptional pathways that allow macrophages to sense and respond to apoptotic …

Liver X receptors (LXRs) are regulators of cholesterol metabolism that also modulate
immune responses. Inactivation of LXR α and β in mice leads to autoimmunity; however …

Ligand activation of liver X receptors (LXRs) has been shown to impact both lipid
metabolism and inflammation. One complicating factor in studies utilizing synthetic LXR …

Coronavirus disease 2019 (COVID-19) exhibits a sex bias with males showing signs of more
severe disease and hospitalizations compared with females. The mechanisms are not clear …

The disruption of methionine (L-MET) metabolism has been linked with neurodevelopmental
disorders such as autism and schizophrenia and neurodegenerative disorders such as …

Macrophage lipid metabolism and inflammatory responses are both regulated by the
nuclear receptors PPAR and LXR. Emerging links between inflammation and metabolic …

Intratumoral delivery of plasmid IL12 via electroporation (IT-tavo-EP) induces localized
expression of IL12 leading to regression of treated and distant tumors with durable …

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis,
but the relative importance of the two LXRs in atheroprotection is incompletely understood …

Clinical studies have demonstrated that local expression of the cytokine IL-12 drives
interferon-gamma expression and recruits T cells to the tumor microenvironment, ultimately …

Background Electroporated plasmid IL-12 (TAVO or tavokinogene telseplasmid) is a novel
pro-inflammatory intratumoral therapy with substantial single agent activity in melanoma …