[HTML][HTML] Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade
Activation of systemic immune responses using PD-1 checkpoint inhibitors is an essential
approach to cancer therapy. Yet, the extent of benefit relative to risk of immune related …
approach to cancer therapy. Yet, the extent of benefit relative to risk of immune related …
Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer
Z Khan, F Di Nucci, A Kwan… - Proceedings of the …, 2020 - National Acad Sciences
PD-1 and PD-L1 act to restrict T cell responses in cancer and contribute to self-tolerance.
Consistent with this role, PD-1 checkpoint inhibitors have been associated with immune …
Consistent with this role, PD-1 checkpoint inhibitors have been associated with immune …
Outflow-driven turbulence in molecular clouds
In this paper, we explore the relationship between protostellar outflows and turbulence in
molecular clouds. Using three-dimensional numerical simulations we focus on the …
molecular clouds. Using three-dimensional numerical simulations we focus on the …
Protostellar outflow evolution in turbulent environments
The link between turbulence in star-forming environments and protostellar jets remains
controversial. To explore issues of turbulence and fossil cavities driven by young stellar …
controversial. To explore issues of turbulence and fossil cavities driven by young stellar …
Synthesis and absolute stereochemistry assignment of enantiopure dihydrofuro-and dihydropyrano-quinoline alkaloids
DR Boyd, ND Sharma, SA Barr, JG Carroll… - Journal of the …, 2000 - pubs.rsc.org
The chiral quinoline alkaloids platydesmine 3, platydesmine methosalt 4 and edulinine 9,
have been synthesised in enantiopure form via asymmetric dihydroxylation of the achiral …
have been synthesised in enantiopure form via asymmetric dihydroxylation of the achiral …
Isotropically driven versus outflow driven turbulence: observational consequences for molecular clouds
Feedback from protostellar outflows can influence the nature of turbulence in star-forming
regions even if they are not the primary source of velocity dispersion for all scales of …
regions even if they are not the primary source of velocity dispersion for all scales of …
ON THE ROLE OF AMBIENT ENVIRONMENTS IN THE COLLAPSE OF BONNOR–EBERT SPHERES
We consider the interaction between a marginally stable Bonnor–Ebert (BE) sphere and the
surrounding ambient medium. In particular, we explore how the infall from an evolving …
surrounding ambient medium. In particular, we explore how the infall from an evolving …
Structural and kinetic studies of spin crossover in an Iron (II) complex with a novel tripodal ligand
AHR Al-Obaidi, KB Jensen, JJ McGarvey… - Inorganic …, 1996 - ACS Publications
Configurational and ligand conformational influences on the kinetics of 1A1⇌ 5T2 spin
crossover in the Fe (II) complex with the novel tripodal ligand, 1, 1, 1-tris ((N-(2 …
crossover in the Fe (II) complex with the novel tripodal ligand, 1, 1, 1-tris ((N-(2 …
Accretion in common envelope evolution
Common envelope evolution (CEE) is presently a poorly understood, yet critical, process in
binary stellar evolution. Characterizing the full 3D dynamics of CEE is difficult in part …
binary stellar evolution. Characterizing the full 3D dynamics of CEE is difficult in part …
Mass transfer and disc formation in AGB binary systems
We investigate mass transfer and the formation of discs in binary systems using a
combination of numerical simulations and theory. We consider six models distinguished by …
combination of numerical simulations and theory. We consider six models distinguished by …