Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia
D Sánchez-Martínez, ML Baroni… - Blood, The Journal …, 2019 - ashpublications.org
Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and
no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen …
no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen …
[HTML][HTML] A novel and efficient tandem CD19-and CD22-directed CAR for B cell ALL
SR Zanetti, T Velasco-Hernandez, F Gutierrez-Agüera… - Molecular Therapy, 2022 - cell.com
CD19-directed chimeric antigen receptor (CAR) T cells have yielded impressive response
rates in refractory/relapse B cell acute lymphoblastic leukemia (B-ALL); however, most …
rates in refractory/relapse B cell acute lymphoblastic leukemia (B-ALL); however, most …
Initial report on Spanish pediatric oncologic, hematologic, and post stem cell transplantation patients during SARS‐CoV‐2 pandemic
A Faura, S Rives, Á Lassaletta… - Pediatric blood & …, 2020 - Wiley Online Library
To the Editor: In December 2019, the SARS-CoV-2 outbreak started in China and rapidly
progressed into a pandemic. 1 Spain was one of the first countries in Europe reporting …
progressed into a pandemic. 1 Spain was one of the first countries in Europe reporting …
Haploidentical transplantation in high‐risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish working Group for bone marrow …
A Pérez‐Martínez, C Ferreras, A Pascual… - American Journal of …, 2020 - Wiley Online Library
A total of 192 pediatric patients, median age 8.6 years, with high‐risk hematological
malignancies, underwent haploidentical stem cell transplantation (haplo‐HSCT) using post …
malignancies, underwent haploidentical stem cell transplantation (haplo‐HSCT) using post …
[HTML][HTML] Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia
M Forero-Castro, C Robledo, R Benito… - British journal of …, 2017 - nature.com
Background: In B-cell precursor acute lymphoblastic leukaemia (B-ALL), the identification of
additional genetic alterations associated with poor prognosis is still of importance. We …
additional genetic alterations associated with poor prognosis is still of importance. We …
[HTML][HTML] Genome-wide DNA copy number analysis of acute lymphoblastic leukemia identifies new genetic markers associated with clinical outcome
Identifying additional genetic alterations associated with poor prognosis in acute
lymphoblastic leukemia (ALL) is still a challenge. Aims: To characterize the presence of …
lymphoblastic leukemia (ALL) is still a challenge. Aims: To characterize the presence of …
[HTML][HTML] Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity
SR Zanetti, PA Romecin, M Vinyoles… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Although adoptive transfer of CD19-directed chimeric antigen receptor (CAR) T-
cells (CD19-CAR T-cells) achieves high rates of complete response in patients with B-cell …
cells (CD19-CAR T-cells) achieves high rates of complete response in patients with B-cell …
[HTML][HTML] L-Ferritin: one gene, five diseases; from hereditary hyperferritinemia to hypoferritinemia—Report of new cases
B Cadenas, J Fita-Torró, M Bermúdez-Cortés… - Pharmaceuticals, 2019 - mdpi.com
Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits
that binds and stores iron inside the cell. A variety of mutations have been reported in the L …
that binds and stores iron inside the cell. A variety of mutations have been reported in the L …
[HTML][HTML] Hereditary hyperferritinemia cataract syndrome: ferritin L gene and physiopathology behind the disease—report of new cases
F Celma Nos, G Hernández, X Ferrer-Cortès… - International Journal of …, 2021 - mdpi.com
Hereditary hyperferritinemia-cataract syndrome (HHCS) is a rare disease characterized by
high serum ferritin levels, congenital bilateral cataracts, and the absence of tissue iron …
high serum ferritin levels, congenital bilateral cataracts, and the absence of tissue iron …
Genetic and phenotypic findings in 34 novel Spanish patients with DDX3X neurodevelopmental disorder
A Parra, P Pascual, M Cazalla, P Arias… - Clinical …, 2024 - Wiley Online Library
DDX3X is a multifunctional ATP‐dependent RNA helicase involved in several processes of
RNA metabolism and in other biological pathways such as cell cycle control, innate …
RNA metabolism and in other biological pathways such as cell cycle control, innate …