Cancers express tumor-associated antigens that should elicit immune response to
antagonize the tumor growth, but spontaneous immune rejection of established cancer is …

The immune checkpoint blockade-based immunotherapies are revolutionizing cancer
management. Tumor-associated neutrophils (TANs) were recently highlighted to have a …

In the past decade, radiation therapy (RT) entered the era of personalized medicine,
following the striking improvements in radiation delivery and treatment planning …

Infiltration and dysfunction of immune cells have been documented in many types of
cancers. We previously reported that plasmacytoid dendritic cells (pDC) within primary …

INTRODUCTION Myeloid cells have emerged as key regulators of cancer growth because of
their abundance in the tumor stroma in a broad range of cancers, their association with …

Neutrophils are an essential part of the innate immune system. To study their importance,
experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti …

In ovarian cancer, the immune system fails to eradicate established tumors partly due to the
induction of immune tolerance within tumor microenvironment. In this study, we investigated …

Human breast tumors are infiltrated by memory CD4+ T cells along with increased numbers
of regulatory T cells (Treg) and plasmacytoid dendritic cells (pDC) that facilitate immune …

Understanding the immune compartment of tumors facilitates the development of
revolutionary new therapies. We used a Kras (G12D)-driven mouse model of lung cancer to …

In breast carcinomas, patient survival seems to be negatively affected by the recruitment of
regulatory T cells (Treg) within lymphoid aggregates by CCL22. However, the mechanisms …