User profiles for "author:Junko Matsuzaki"
 | Junko MatsuzakiUniversity of Chicago Verified email at bsd.uchicago.edu Cited by 5751 |
Tumor-infiltrating NY-ESO-1–specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
J Matsuzaki, S Gnjatic… - Proceedings of the …, 2010 - National Acad Sciences
NY-ESO-1 is a “cancer-testis” antigen frequently expressed in epithelial ovarian cancer
(EOC) and is among the most immunogenic tumor antigens defined to date. In an effort to …
(EOC) and is among the most immunogenic tumor antigens defined to date. In an effort to …
Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer
Despite the important role of Th17 cells in the pathogenesis of many autoimmune diseases,
their prevalence and the mechanisms by which they are generated and regulated in cancer …
their prevalence and the mechanisms by which they are generated and regulated in cancer …
[HTML][HTML] LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
RY Huang, C Eppolito, S Lele, P Shrikant, J Matsuzaki… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The immune co-inhibitory receptors lymphocyte activation gene-3 (LAG3) and programmed
cell death 1 (PD1) synergistically contribute to autoimmunity and tumor evasion. Here we …
cell death 1 (PD1) synergistically contribute to autoimmunity and tumor evasion. Here we …
Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer
K Odunsi, F Qian, J Matsuzaki… - Proceedings of the …, 2007 - National Acad Sciences
NY-ESO-1 is a “cancer-testis” antigen expressed in epithelial ovarian cancer (EOC) and is
among the most immunogenic tumor antigens defined to date. The NY-ESO-1 peptide …
among the most immunogenic tumor antigens defined to date. The NY-ESO-1 peptide …
Immunosteroid as a regulator for Th1/Th2 balance: its possible role in autoimmune diseases
Immune balance controlled by Th1 and Th2 cells is critical for the protection of host from
pathogenic invasion while its imbalance becomes the cause of various immune disorders …
pathogenic invasion while its imbalance becomes the cause of various immune disorders …
Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients
K Odunsi, J Matsuzaki, J Karbach… - Proceedings of the …, 2012 - National Acad Sciences
Recombinant poxviruses (vaccinia and fowlpox) expressing tumor-associated antigens are
currently being evaluated in clinical trials as cancer vaccines to induce tumor-specific …
currently being evaluated in clinical trials as cancer vaccines to induce tumor-specific …
Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer
K Odunsi, J Matsuzaki, SR James… - Cancer immunology …, 2014 - AACR
The cancer–testis/cancer germline antigen, NY-ESO-1, is a vaccine target in epithelial
ovarian cancer (EOC), but its limited expression is a barrier to vaccine efficacy. As NY-ESO …
ovarian cancer (EOC), but its limited expression is a barrier to vaccine efficacy. As NY-ESO …
CXCR3+ T Regulatory Cells Selectively Accumulate in Human Ovarian Carcinomas to Limit Type I Immunity
N Redjimi, C Raffin, I Raimbaud, P Pignon, J Matsuzaki… - Cancer research, 2012 - AACR
Antitumor type I T-cell responses involving IFN-γ production are critical to control cancer, but
the efficacy of this response is limited by a variety of immunosuppressive mechanisms that …
the efficacy of this response is limited by a variety of immunosuppressive mechanisms that …
Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2, 3-dioxygenase–mediated arrest of T-cell proliferation in human …
F Qian, J Villella, PK Wallace, P Mhawech-Fauceglia… - Cancer research, 2009 - AACR
It has been reported that levo-1-methyl tryptophan (L-1MT) can block indoleamine-2, 3-
dioxygenase (IDO) expressed by human dendritic cells (DC), whereas dextro-1-methyl …
dioxygenase (IDO) expressed by human dendritic cells (DC), whereas dextro-1-methyl …
[HTML][HTML] Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity
Diet-derived nutrients are inextricably linked to human physiology by providing energy and
biosynthetic building blocks and by functioning as regulatory molecules. However, the …
biosynthetic building blocks and by functioning as regulatory molecules. However, the …