Immune checkpoint inhibitors for cancer treatment

J Park, M Kwon, EC Shin - Archives of pharmacal research, 2016 - Springer
During immune responses antigen-specific T cells are regulated by several mechanisms,
including through inhibitory receptors and regulatory T cells, to avoid excessive or persistent …

Reinforcing effects of carbon nanotubes in structural aluminum matrix nanocomposites

H Choi, J Shin, B Min, J Park, D Bae - Journal of Materials Research, 2009 - cambridge.org
The reinforcing effects of carbon nanotubes (CNTs) are investigated for aluminum matrix
composites. The composites present a strong bonding between CNTs and the aluminum …

A hybrid bilevel model for the optimal shelter assignment in emergency evacuations

MW Ng, J Park, ST Waller - Computer‐Aided Civil and …, 2010 - Wiley Online Library
The rise in natural and man‐made disasters in recent years has led to an increased interest
in emergency evacuation planning. Athough the vast majority of the existing evacuation …

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

JH Kim, YJ Choi, BH Lee, MY Song, CY Ban… - Journal of Allergy and …, 2016 - Elsevier
Background Psoriasis is one of the most common chronic inflammatory diseases of the skin.
Recently, IL-17–producing T cells have been shown to play a critical role in psoriatic …

[HTML][HTML] 4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39+ CD8 T cells from primary and metastatic sites of epithelial …

G Leem, J Park, M Jeon, ES Kim, SW Kim… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Responses to immunotherapy vary between different cancer types and sites.
Here, we aimed to investigate features of exhaustion and activation in tumor-infiltrating CD8 …

[HTML][HTML] Premenstrual syndrome and premenstrual dysphoric disorder in perimenopausal women

SH Chung, TH Kim, HH Lee, A Lee… - Journal of …, 2014 - ncbi.nlm.nih.gov
Objectives To evaluate the prevalence of premenstrual syndrome (PMS) and premenstrual
dysphoric disorder (PMDD) of perimenopausal women at a university hospital along with …

[HTML][HTML] Risk of COVID-19 infection in public transportation: The development of a model

J Park, G Kim - International journal of environmental research and …, 2021 - mdpi.com
South Korea's social distancing policies on public transportation only involve mandatory
wearing of masks and prohibition of food intake, similar to policies on other indoor spaces …

Immune Checkpoint Inhibitor-induced Reinvigoration of Tumor-infiltrating CD8+ T Cells is Determined by Their Differentiation Status in Glioblastoma

J Park, M Kwon, KH Kim, TS Kim, SH Hong… - Clinical Cancer …, 2019 - AACR
Purpose: Immune checkpoint inhibitors (ICI) are used for the treatment of various cancers,
but clinical trials of anti-programmed cell death protein 1 (PD-1) with patients with recurrent …

Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma

AR Kim, SJ Choi, J Park, M Kwon, T Chowdhury… - …, 2022 - Taylor & Francis
The tumor immune microenvironment (TIME) in high-grade glioma (HGG) exhibits high
spatial heterogeneity. Though the tumor core and peripheral regions have different …

Functions of human liver CD69+ CD103-CD8+ T cells depend on HIF-2α activity in healthy and pathologic livers

JH Kim, JW Han, YJ Choi, MS Rha, JY Koh, KH Kim… - Journal of …, 2020 - Elsevier
Background & Aims Human liver CD69+ CD8+ T cells are~ 95% CD103-and~ 5% CD103+.
Although CD69+ CD103+ CD8+ T cells show tissue residency and robustly respond to …