Spontaneous tumor-initiated T cell priming is dependent on IFN-β production by tumor-
resident dendritic cells. On the basis of recent observations indicating that IFN-β expression …

Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous
and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon …

Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet
factors dictating the balance between innate and adaptive anti-tumor immunity are unclear …

There are a limited number of adjuvants that elicit effective cell-based immunity required for
protection against intracellular bacterial pathogens. Here, we report that STING-activating …

(Cell Reports 25, 3074–3085. e1–e5; December 11, 2018) In the originally published
version of this article, the 4T1 tumor cell line described in Figures 1, 2, and 5 and …

Reductive lithiation and cyclization of N-Boc α-amino nitriles are often highly stereoselective.
The alkyllithium intermediates are formed with varying levels of selectivity, but the …

Recent reports have provided the mechanistic insight of how innate immune activation
promotes priming of anti-tumor immunity and inform the development of clinical approaches …

Abstract Stimulator of Interferon Genes (STING) is a critical signaling sensor of the innate
immune system. STING binds cyclic dinucleotides (CDN) produced by an intracellular …

Innate immune sensing in the tumor microenvironment is a critical step in promoting tumor
infiltrating lymphocytes (TILs) and spontaneous anti-tumor T cell priming. Transcriptional …

Stimulator of interferon genes (STING) is a critical component of an innate immune pathway
that activates robust antiviral and antitumor responses in mouse models. Activation of the …