Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …

Cytotoxic T cells are essential mediators of protective immunity to viral infection and
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …

Staining and scanning of tissue samples for microscopic examination is fraught with
undesirable color variations arising from differences in raw materials and manufacturing …

The poor correlation of mutational landscapes with phenotypes limits our understanding of
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …

T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …

We used whole-genome and transcriptome sequencing to identify clinically actionable
genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC) …

Here, we show CRISPR/Cas9-based targeted somatic multiplex-mutagenesis and its
application for high-throughput analysis of gene function in mice. Using hepatic single guide …

SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in
physiology and disease are believed to be linked to its role as a master regulator of …

Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited
by the long duration of allele/model generation. Here we show transfection-based …

Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but
whether this determines protective versus ineffective anti-cancer immunity is poorly …