User profiles for "author:Kobe Yuen"

Kobe C. Yuen

Genentech
Verified email at gene.com
Cited by 5079

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

S Mariathasan, SJ Turley, D Nickles, A Castiglioni… - Nature, 2018 - nature.com
Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-
ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various …

ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

T Powles, ZJ Assaf, N Davarpanah, R Banchereau… - Nature, 2021 - nature.com
Minimally invasive approaches to detect residual disease after surgery are needed to
identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA …

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

KC Yuen, LF Liu, V Gupta, S Madireddi… - Nature medicine, 2020 - nature.com
Although elevated plasma interleukin-8 (pIL-8) has been associated with poor outcome to
immune checkpoint blockade, this has not been comprehensively evaluated in large …

[HTML][HTML] Taking cohesin and condensin in context

KC Yuen, JL Gerton - PLoS genetics, 2018 - journals.plos.org
Structural maintenance of chromosome (SMC) protein complexes, including cohesin and
condensin, are increasingly being recognized for their important role in cancer and …

[PDF][PDF] CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

MA Huseni, L Wang, JE Klementowicz, K Yuen… - Cell Reports …, 2023 - cell.com
Although immune checkpoint inhibitors (ICIs) are established as effective cancer therapies,
overcoming therapeutic resistance remains a critical challenge. Here we identify interleukin …

Etiology and pathogenesis of the cohesinopathies

M Zakari, K Yuen, JL Gerton - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
Cohesin is a chromosome‐associated protein complex that plays many important roles in
chromosome function. Genetic screens in yeast originally identified cohesin as a key …

Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial

T Powles, KC Yuen, S Gillessen, EE Kadel Iii… - Nature medicine, 2022 - nature.com
Early clinical data indicate that some patients with castration-resistant prostate cancer may
benefit from program death ligand-1 (PD-L1) inhibition, especially with enzalutamide. The …

[PDF][PDF] The immunoglobulin superfamily receptome defines cancer-relevant networks associated with clinical outcome

E Verschueren, B Husain, K Yuen, Y Sun, S Paduchuri… - Cell, 2020 - cell.com
Cell surface receptors and their interactions play a central role in physiological and
pathological signaling. Despite its clinical relevance, the immunoglobulin superfamily (IgSF) …

Safety and clinical activity of atezolizumab in patients with metastatic castration-resistant prostate cancer: a phase I study

DP Petrylak, Y Loriot, DR Shaffer, F Braiteh… - Clinical Cancer …, 2021 - AACR
Purpose: Atezolizumab [anti–programmed death-ligand 1 (anti-PD-L1)] is well tolerated and
efficacious in multiple cancers, but has not been previously evaluated in metastatic …

Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters

KC Yuen, BD Slaughter, JL Gerton - Science advances, 2017 - science.org
Structural maintenance of chromosome complexes, such as cohesin, have been implicated
in a wide variety of chromatin-dependent functions such as genome organization …