User profiles for "author:Kobe Yuen"
Kobe C. YuenGenentech Verified email at gene.com Cited by 5079 |
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-
ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various …
ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various …
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma
T Powles, ZJ Assaf, N Davarpanah, R Banchereau… - Nature, 2021 - nature.com
Minimally invasive approaches to detect residual disease after surgery are needed to
identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA …
identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA …
High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
KC Yuen, LF Liu, V Gupta, S Madireddi… - Nature medicine, 2020 - nature.com
Although elevated plasma interleukin-8 (pIL-8) has been associated with poor outcome to
immune checkpoint blockade, this has not been comprehensively evaluated in large …
immune checkpoint blockade, this has not been comprehensively evaluated in large …
[HTML][HTML] Taking cohesin and condensin in context
Structural maintenance of chromosome (SMC) protein complexes, including cohesin and
condensin, are increasingly being recognized for their important role in cancer and …
condensin, are increasingly being recognized for their important role in cancer and …
[PDF][PDF] CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy
MA Huseni, L Wang, JE Klementowicz, K Yuen… - Cell Reports …, 2023 - cell.com
Although immune checkpoint inhibitors (ICIs) are established as effective cancer therapies,
overcoming therapeutic resistance remains a critical challenge. Here we identify interleukin …
overcoming therapeutic resistance remains a critical challenge. Here we identify interleukin …
Etiology and pathogenesis of the cohesinopathies
Cohesin is a chromosome‐associated protein complex that plays many important roles in
chromosome function. Genetic screens in yeast originally identified cohesin as a key …
chromosome function. Genetic screens in yeast originally identified cohesin as a key …
Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial
T Powles, KC Yuen, S Gillessen, EE Kadel Iii… - Nature medicine, 2022 - nature.com
Early clinical data indicate that some patients with castration-resistant prostate cancer may
benefit from program death ligand-1 (PD-L1) inhibition, especially with enzalutamide. The …
benefit from program death ligand-1 (PD-L1) inhibition, especially with enzalutamide. The …
[PDF][PDF] The immunoglobulin superfamily receptome defines cancer-relevant networks associated with clinical outcome
E Verschueren, B Husain, K Yuen, Y Sun, S Paduchuri… - Cell, 2020 - cell.com
Cell surface receptors and their interactions play a central role in physiological and
pathological signaling. Despite its clinical relevance, the immunoglobulin superfamily (IgSF) …
pathological signaling. Despite its clinical relevance, the immunoglobulin superfamily (IgSF) …
Safety and clinical activity of atezolizumab in patients with metastatic castration-resistant prostate cancer: a phase I study
DP Petrylak, Y Loriot, DR Shaffer, F Braiteh… - Clinical Cancer …, 2021 - AACR
Purpose: Atezolizumab [anti–programmed death-ligand 1 (anti-PD-L1)] is well tolerated and
efficacious in multiple cancers, but has not been previously evaluated in metastatic …
efficacious in multiple cancers, but has not been previously evaluated in metastatic …
Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters
Structural maintenance of chromosome complexes, such as cohesin, have been implicated
in a wide variety of chromatin-dependent functions such as genome organization …
in a wide variety of chromatin-dependent functions such as genome organization …