Cellular responses to DNA damage are mediated by a number of protein kinases, including
ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the …

Fanconi anemia (FA) is a developmental and cancer-predisposition syndrome caused by
mutations in genes controlling DNA interstrand crosslink repair. Several FA proteins form a …

Many proteins that respond to DNA damage are recruited to DNA lesions. We used a
proteomics approach that coupled isotopic labeling with chromatin fractionation and mass …

Elucidation of the mutational landscape of human cancer has progressed rapidly and been
accompanied by the development of therapeutics targeting mutant oncogenes. However, a …

5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage
pathway. The MTAP gene is frequently deleted in human cancers because of its …

The BCL-2 family of apoptotic proteins encompasses key regulators proximal to irreversible
cell damage. The BH3-only members of this family act as sentinels, interconnecting specific …

In response to DNA damage, cells activate a complex signal transduction network called the
DNA damage response (DDR). To enhance our current understanding of the DDR network …

The DNA damage response (DDR) is brought about by a protein kinase cascade that
orchestrates DNA repair through transcriptional and posttranslational mechanisms. Cell …

The ability to sense and respond to DNA damage is critical to maintenance of genomic
stability and the prevention of cancer. In this study, we employed a genetic screen to identify …

The ATR-mediated checkpoint is not only critical for responding to genotoxic stress but also
essential for cell proliferation. The RFC-related checkpoint protein Rad17, a phosphorylation …