Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often
lethal when relapse occurs. We here used whole-exome sequencing, mRNA expression …

Purpose: Targeting BET proteins was previously shown to have specific antitumoral efficacy
against MYCN-amplified neuroblastoma. We here assess the therapeutic efficacy of the BET …

Medulloblastoma is the most common malignant brain tumor of childhood, and represents a
significant clinical challenge in pediatric oncology, since overall survival currently remains …

Neuroblastoma, a childhood cancer that originates from neural crest-derived cells, is the
most common deadly solid tumor of infancy. Amplification of the MYCN oncogene, which …

Neuroblastoma is the most common extracranial solid tumor of childhood, and accounts
for∼ 15% of all childhood cancer deaths. The histone demethylase, lysine‐specific …

Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-
cell infiltration and the number of neoantigens caused by tumor-specific mutations are …

MicroRNAs (miRNAs) are deregulated in a variety of human cancers, including
neuroblastoma, the most common extracranial tumor of childhood. We previously reported a …

Immune evasion is indispensable for cancer initiation and progression, although its
underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known …

Isoforms of protein kinase Akt are involved in essential processes including cell proliferation,
survival, and metabolism. However, their individual roles in health and disease have not …

LIN28B has been identified as an oncogene in various tumor entities, including
neuroblastoma, a childhood cancer that originates from neural crest-derived cells, and is …