The dynamic interplay between cancer and host immune system often affects the process of
myelopoiesis. As a consequence, tumor‐derived factors sustain the accumulation and …

Study of myeloid cells endowed with suppressive activity is an active field of research which
has particular importance in cancer, in view of the negative regulatory capacity of these cells …

Immune checkpoint inhibitors are becoming standard treatments in several cancer types,
profoundly changing the prognosis of a fraction of patients. Currently, many efforts are being …

BACKGROUND Patients with coronavirus disease 2019 (COVID-19) develop pneumonia
generally associated with lymphopenia and a severe inflammatory response due to …

We recently demonstrated that human BM cells can be treated in vitro with defined growth
factors to induce the rapid generation of myeloid-derived suppressor cells (MDSCs) …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with
an overall 5-year survival rate of less than 8%. New evidence indicates that PDAC cells …

Background Systemic and local immune suppression plays a significant role in glioma
progression. Glioma microenvironment contains both brain-resident microglial cells (MG) …

Tumor-induced expansion of myeloid-derived suppressor cells (MDSCs) is known to impair
the efficacy of cancer immunotherapy. Among pharmacological approaches for MDSC …

The expansion of myeloid derived suppressor cells (MDSCs), a suppressive population able
to hamper the immune response against cancer, correlates with tumor progression and …

This unit presents methods to assess the immunosuppressive properties of
immunoregulatory cells of myeloid origin, such as myeloid‐derived suppressor cells …