Nitric oxide (NO) is implicated as an integral component of the host armament against
invading parasites. Strongest evidence has come from laboratory models of protozoan …

As cancer strikes, individuals vary not only in terms of factors that contribute to its occurrence
and development, but as importantly, in their capacity to respond to treatment. While exciting …

The components of the innate immune system that are involved in responses to
mycobacteria overlap with those implicated in allergic disorders. Polymorphisms might …

Borrelia burgdorferi, the spirochetal agent of Lyme disease, is transmitted by Ixodes ticks. A
vaccine based on B. burgdorferi outer surface protein (Osp) A protects mice from spirochete …

To examine the role of the Th2-type response during schistosomiasis mansoni we compared
disease progression in wild type (wt), and Th2-response deficient IL-4 (-/-) mice. Whereas wt …

Peripheral immune activation can have profound physiological and behavioral effects
including induction of fever and sickness behavior. One mechanism through which immune …

BACKGROUND: Lone Star ticks (Amblyomma americanum) have been suggested as a
vector of the agent of Lyme disease (Borrelia burgdorferi sensu lato) in the USA, based on …

Rationale Mycobacterium vaccae (NCTC 11659) is an environmental saprophytic bacterium
with anti-inflammatory, immunoregulatory, and stress resilience properties. Previous studies …

The hygiene hypothesis proposes that common, harmless microorganisms, present
throughout our evolutionary history, have helped to develop immunoregulatory mechanisms …

To address the question of how the murine host responds to a prototypic type 1 cytokine
inducer while concurrently undergoing a helminth-induced type 2 cytokine response …