Over the past decade, immunotherapy has become a powerful and evident tool in the fight
against cancers. Notably, the rise of checkpoint blockade using monoclonal antibodies (anti …

Introduction: The recent success of checkpoint-inhibitors in cancer treatment paved the way
for the development of new strategies of agonist and antagonist agents against B7 …

Introduction: The promotion of antitumor response by targeting co-stimulatory B7 superfamily
members has become evident to create a new wave of cancer immunotherapy. Inducible Co …

Metabolic regulation has been recognized as a powerful principle guiding immune
responses. Inflammatory macrophages undergo extensive metabolic rewiring marked by the …

Macrophages are critical components of the innate and adaptive immune responses, and
they are the first line of defense against foreign invaders because of their powerful …

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for
antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we …

Endometrial Cancer is the most common cancer in the female genital tract in developed
countries, and with its increasing incidence due to risk factors such as aging and obesity …

The anti-tumor response of Vγ9Vδ2 T cells requires the sensing of accumulated
phosphoantigens (pAgs) bound intracellularly to butyrophilin 3A1 (BTN3A1). In this study …

Endometrial cancer (EC) can easily be cured when diagnosed at an early stage. However,
advanced and metastatic EC is a common disease, affecting more than 15,000 patients per …

Natural killer (NK) cells are major antileukemic immune effectors. Leukemic blasts have a
negative impact on NK cell function and promote the emergence of phenotypically and …