[HTML][HTML] Combinatorial PD-1 blockade and CD137 activation has therapeutic efficacy in murine cancer models and synergizes with cisplatin

H Wei, L Zhao, W Li, K Fan, W Qian, S Hou, H Wang… - PloS one, 2013 - journals.plos.org
There is an urgent need for improved therapy for advanced ovarian carcinoma, which may
be met by administering immune-modulatory monoclonal antibodies (mAbs) to generate a …

[HTML][HTML] Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

G Li, L Zhao, W Li, K Fan, W Qian, S Hou, H Wang… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Although HER2-targeting antibody trastuzumab confers a substantial benefit for patients with
HER2-overexpressing breast and gastric cancer, overcoming trastuzumab resistance …

Dual targeting of CD137 co-stimulatory and PD-1 co-inhibitory molecules for ovarian cancer immunotherapy

H Wei, L Zhao, I Hellstrom, KE Hellstrom… - Oncoimmunology, 2014 - Taylor & Francis
We recently demonstrated that simultaneous targeting of CD137 co-stimulatory and
programmed cell death 1 (PD-1) co-inhibitory molecules synergistically induced an …

[HTML][HTML] Coffee-associated endophytes: Plant growth promotion and crop protection

S Asad, AKH Priyashantha, S Tibpromma, Y Luo… - Biology, 2023 - mdpi.com
Simple Summary Several hundreds of endophytic microbes are found to be associated with
coffee plants. Endophytes are mostly recognized as symbionts and offer many benefits to …

[HTML][HTML] Bispecific antibody targeting TROP2xCD3 suppresses tumor growth of triple negative breast cancer

H Liu, L Bai, L Huang, N Ning, L Li, Y Li… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Triple negative breast cancer (TNBC) is a subtype of breast cancers with poor
prognosis and targeted drug therapies are limited. To develop novel and efficacious …

Using Naive Bayes Classifier to predict osteonecrosis of the femoral head with cannulated screw fixation

S Cui, L Zhao, Y Wang, Q Dong, J Ma, Y Wang, W Zhao… - Injury, 2018 - Elsevier
Predictive models permitting personalized prognostication for patients with cannulated
screw fixation for the femoral neck fracture before operation are lacking. The objective of this …

A simple molecular beacon with duplex-specific nuclease amplification for detection of microRNA

Y Li, J Zhang, J Zhao, L Zhao, Y Cheng, Z Li - Analyst, 2016 - pubs.rsc.org
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene activity, promoting or
inhibiting cell proliferation, migration and apoptosis. Abnormal expression of miRNAs is …

Influencing factors of bioaugmentation treatment of PAH-contaminated soils in slurry bioreactors

S Bao, L Zhao, Y Liu, L Yang, P Liu, C Chen… - Journal of Environmental …, 2023 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are a group of contaminants with low
bioavailability and biodegradability. As a result, removing PAHs from contaminated soils is …

Propylene glycol-mixed steam enhanced extraction for an efficient and sustainable remediation of PAHs-contaminated soil

R Yue, Z Chen, L Zhao, X Song, C Chen, J Qi… - Journal of Hazardous …, 2023 - Elsevier
An innovative thermal desorption method, propylene glycol (PG)-mixed steam enhanced
extraction, is proposed for a highly efficient remediation of polycyclic aromatic hydrocarbons …

Characterization of the structural ensembles of p53 TAD2 by molecular dynamics simulations with different force fields

Y Ouyang, L Zhao, Z Zhang - Physical Chemistry Chemical Physics, 2018 - pubs.rsc.org
Intrinsically disordered regions (IDRs) or proteins (IDPs), which play crucial biological
functions in essential biological processes of life, do not have well-defined secondary or …