[HTML][HTML] p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β
G Rackov, E Hernández-Jiménez… - The Journal of …, 2016 - Am Soc Clin Investig
M1 and M2 macrophage phenotypes, which mediate proinflammatory and antiinflammatory
functions, respectively, represent the extremes of immunoregulatory plasticity in the …
functions, respectively, represent the extremes of immunoregulatory plasticity in the …
[HTML][HTML] SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
E Mira, L Carmona-Rodríguez, B Pérez-Villamil… - Nature …, 2018 - nature.com
One drawback of chemotherapy is poor drug delivery to tumor cells, due in part to
hyperpermeability of the tumor vasculature. Extracellular superoxide dismutase (SOD3) is …
hyperpermeability of the tumor vasculature. Extracellular superoxide dismutase (SOD3) is …
[HTML][HTML] A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors
E Mira, L Carmona-Rodríguez, M Tardáguila… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Beyond their ability to inhibit cholesterol biosynthesis, the statins have pleiotropic effects that
include anti-inflammatory and immunomodulatory activities. Statins could have clinical utility …
include anti-inflammatory and immunomodulatory activities. Statins could have clinical utility …
[HTML][HTML] Extracellular superoxide dismutase, the endothelial basement membrane, and the wnt pathway: new players in vascular normalization and tumor infiltration …
D Martínez-Rey, L Carmona-Rodríguez… - Frontiers in …, 2020 - frontiersin.org
Tumor-infiltrating lymphocytes (TILs) are major players in the immune-mediated control of
cancer and the response to immunotherapy. In primary cancers, however, TILs are …
cancer and the response to immunotherapy. In primary cancers, however, TILs are …
[HTML][HTML] SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells
L Carmona-Rodríguez, D Martínez-Rey… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Tumor-infiltrating lymphocytes (TILs), mainly CD8+ cytotoxic T lymphocytes
(CTL), are linked to immune-mediated control of human cancers and response to …
(CTL), are linked to immune-mediated control of human cancers and response to …
Molecular insights of cholestasis in mdr2 knockout murine liver organoids
I Blázquez-García, L Guerrero… - Journal of Proteome …, 2024 - ACS Publications
MDR3 (multidrug resistance 3) deficiency in humans (MDR2 in mice) causes progressive
familial intrahepatic cholestasis type 3 (PFIC3). PFIC3 is a lethal disease characterized by …
familial intrahepatic cholestasis type 3 (PFIC3). PFIC3 is a lethal disease characterized by …
Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases
L Carmona‐Rodríguez, AS Gajadhar… - …, 2023 - Wiley Online Library
The liver is the only solid organ capable of regenerating itself to regain 100% of its mass and
function after liver injury and/or partial hepatectomy (PH). This exceptional property …
function after liver injury and/or partial hepatectomy (PH). This exceptional property …
[HTML][HTML] Physical Exercise following bariatric surgery in women with Morbid obesity: Study protocol clinical trial (SPIRIT compliant)
A Soriano-Maldonado, S Martínez-Forte… - Medicine, 2020 - journals.lww.com
Background: Severe and morbid obesity are increasing globally, particularly in women. As
BMI increases, the likelihood of anovulation is higher. The primary aim of the EMOVAR …
BMI increases, the likelihood of anovulation is higher. The primary aim of the EMOVAR …
[HTML][HTML] Mapping the serum proteome of COVID-19 patients; guidance for severity assessment
E Nuñez, I Orera, L Carmona-Rodríguez, JR Paño… - Biomedicines, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), whose outbreak in 2019 led to an ongoing pandemic with …
coronavirus 2 (SARS-CoV-2), whose outbreak in 2019 led to an ongoing pandemic with …
SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
L Carmona-Rodríguez, D Martínez-Rey, E Mira… - …, 2020 - Taylor & Francis
The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment
(TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that …
(TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that …