Naturally simian immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to
AIDS despite high-level virus replication. We previously showed that the fraction of CD4+ …

Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals but does
not eliminate the reservoir of latently infected cells. Recent work identified PD-1+ follicular …

In rhesus macaques (RMs), experimental depletion of CD4+ T-cells prior to SIV infection
results in higher viremia and emergence of CD4-independent SIV-envelopes. In this study …

The primary human immunodeficiency virus (HIV) reservoir is composed of resting memory
CD4+ T cells, which often express the immune checkpoint receptors programmed cell death …

Despite successful control of viremia, many HIV-infected individuals given antiretroviral
therapy (ART) exhibit residual inflammation, which is associated with non–AIDS-related …

HIV-1 infection is characterized by varying degrees of chronic immune activation and
disruption of T-cell homeostasis, which impact the rate of disease progression. A deeper …

In pathogenic HIV and SIV infections of humans and rhesus macaques (RMs), preferential
depletion of CD4+ Th17 cells correlates with mucosal immune dysfunction and disease …

Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to
regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV …

Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy,
nonpathogenic infections in natural hosts, such African green monkeys, are characterized by …

In HIV/SIV-infected humans and rhesus macaques (RMs), a severe depletion of intestinal
CD4+ T-cells producing interleukin IL-17 and IL-22 associates with loss of mucosal integrity …