[HTML][HTML] Oncolytic DNX-2401 virus for pediatric diffuse intrinsic pontine glioma
J Gállego Pérez-Larraya, M Garcia-Moure… - … England Journal of …, 2022 - Mass Medical Soc
Background Pediatric patients with diffuse intrinsic pontine glioma (DIPG) have a poor
prognosis, with a median survival of less than 1 year. Oncolytic viral therapy has been …
prognosis, with a median survival of less than 1 year. Oncolytic viral therapy has been …
[HTML][HTML] The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
N Martínez-Vélez, M Garcia-Moure, M Marigil… - Nature …, 2019 - nature.com
Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are
aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic …
aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic …
[PDF][PDF] TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
I Ausejo-Mauleon, S Labiano, D de la Nava… - Cancer cell, 2023 - cell.com
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain stem tumor and the leading
cause of pediatric cancer-related death. To date, these tumors remain incurable …
cause of pediatric cancer-related death. To date, these tumors remain incurable …
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 …
A Patiño-García, M Zalacaín, L Marrodán… - The Journal of …, 2009 - Elsevier
OBJECTIVE: To determine the influence of the genotype and the level of expression of
different enzymes involved in folate metabolism on the response to and toxicity of high-dose …
different enzymes involved in folate metabolism on the response to and toxicity of high-dose …
[HTML][HTML] CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models
M Puigdelloses, M Garcia-Moure… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Glioblastoma (GBM) is a devastating primary brain tumor with a highly
immunosuppressive tumor microenvironment, and treatment with oncolytic viruses (OVs) …
immunosuppressive tumor microenvironment, and treatment with oncolytic viruses (OVs) …
[HTML][HTML] Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas
V Laspidea, M Puigdelloses, S Labiano, L Marrodán… - JCI insight, 2022 - ncbi.nlm.nih.gov
Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors, and patient
survival has not changed despite many therapeutic efforts, emphasizing the urgent need for …
survival has not changed despite many therapeutic efforts, emphasizing the urgent need for …
The oncolytic adenovirus VCN-01 as therapeutic approach against pediatric osteosarcoma
N Martínez-Vélez, E Xipell, B Vera… - Clinical Cancer …, 2016 - AACR
Purpose: Osteosarcoma is the most common malignant bone tumor in children and
adolescents. Despite aggressive chemotherapy, more than 30% of patients do not respond …
adolescents. Despite aggressive chemotherapy, more than 30% of patients do not respond …
Delta-24-RGD, an oncolytic adenovirus, increases survival and promotes proinflammatory immune landscape remodeling in models of AT/RT and CNS-PNET
M Garcia-Moure, M Gonzalez-Huarriz, S Labiano… - Clinical Cancer …, 2021 - AACR
Purpose: Atypical teratoid/rhabdoid tumors (AT/RT) and central nervous system primitive
neuroectodermal tumors (CNS-PNET) are pediatric brain tumors with poor survival and life …
neuroectodermal tumors (CNS-PNET) are pediatric brain tumors with poor survival and life …
The oncolytic adenovirus Δ24‐RGD in combination with cisplatin exerts a potent anti‐osteosarcoma activity
N Martinez‐Velez, E Xipell, P Jauregui… - Journal of bone and …, 2014 - academic.oup.com
Osteosarcoma is the most common malignant bone tumor in children and adolescents. The
presence of metastases and the lack of response to conventional treatment are the major …
presence of metastases and the lack of response to conventional treatment are the major …
Local treatment of a pediatric osteosarcoma model with a 4-1BBL armed oncolytic adenovirus results in an antitumor effect and leads to immune memory
N Martinez-Velez, V Laspidea, M Zalacain… - Molecular cancer …, 2022 - AACR
Osteosarcoma is an aggressive bone tumor occurring primarily in pediatric patients. Despite
years of intensive research, the outcomes of patients with metastatic disease or those who …
years of intensive research, the outcomes of patients with metastatic disease or those who …