[HTML][HTML] Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
Recent studies have offered ample insight into genome-wide expression patterns to define
pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of …
pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of …
[PDF][PDF] Pancreatic adenocarcinoma therapeutic targets revealed by tumor-stroma cross-talk analyses in patient-derived xenografts
Preclinical models based on patient-derived xenografts have remarkable specificity in
distinguishing transformed human tumor cells from non-transformed murine stromal cells …
distinguishing transformed human tumor cells from non-transformed murine stromal cells …
[HTML][HTML] Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
Y Blum, C Meiller, L Quetel, N Elarouci, M Ayadi… - Nature …, 2019 - nature.com
Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both on
histology and molecular profiling. Histology addresses inter-tumor and intra-tumor …
histology and molecular profiling. Histology addresses inter-tumor and intra-tumor …
[HTML][HTML] Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer
R Nicolle, Y Blum, P Duconseil, C Vanbrugghe… - …, 2020 - thelancet.com
Background A significant gap in pancreatic ductal adenocarcinoma (PDAC) patient's care is
the lack of molecular parameters characterizing tumours and allowing a personalized …
the lack of molecular parameters characterizing tumours and allowing a personalized …
[HTML][HTML] Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression
Chondrosarcomas are primary cancers of cartilaginous tissue with highly contrasting
prognoses. These tumors are defined by recurrent mutations in the IDH genes and other …
prognoses. These tumors are defined by recurrent mutations in the IDH genes and other …
[HTML][HTML] Investigation of radiosensitivity gene signatures in cancer cell lines
JS Hall, R Iype, J Senra, J Taylor, L Armenoult… - PloS one, 2014 - journals.plos.org
Intrinsic radiosensitivity is an important factor underlying radiotherapy response, but there is
no method for its routine assessment in human tumours. Gene signatures are currently …
no method for its routine assessment in human tumours. Gene signatures are currently …
[HTML][HTML] Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer
R Cohen, V Jonchère… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Metastatic colorectal cancers (mCRC) harboring microsatellite instability (MSI) are sensitive
to immune checkpoint inhibitors (ICIs), but the mechanisms of resistance to ICIs remain …
to immune checkpoint inhibitors (ICIs), but the mechanisms of resistance to ICIs remain …
[HTML][HTML] Identification of positively and negatively selected driver gene mutations associated with colorectal cancer with microsatellite instability
V Jonchère, L Marisa, M Greene, A Virouleau… - Cellular and molecular …, 2018 - Elsevier
Background & Aims Recent studies have shown that cancers arise as a result of the positive
selection of driver somatic events in tumor DNA, with negative selection playing only a minor …
selection of driver somatic events in tumor DNA, with negative selection playing only a minor …
Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity
JS Hall, R Iype, LSC Armenoult, J Taylor… - International Journal of …, 2013 - Elsevier
PURPOSE: To investigate the relationship between human papillomavirus (HPV) genotype
and outcome after radiation therapy and intrinsic radiosensitivity. METHODS AND …
and outcome after radiation therapy and intrinsic radiosensitivity. METHODS AND …
[HTML][HTML] DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification
C Decamps, A Arnaud, F Petitprez, M Ayadi… - BMC …, 2021 - Springer
Background Quantification of tumor heterogeneity is essential to better understand cancer
progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to …
progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to …