[HTML][HTML] Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

G Lomberk, Y Blum, R Nicolle, A Nair… - Nature …, 2018 - nature.com
Recent studies have offered ample insight into genome-wide expression patterns to define
pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of …

[PDF][PDF] Pancreatic adenocarcinoma therapeutic targets revealed by tumor-stroma cross-talk analyses in patient-derived xenografts

R Nicolle, Y Blum, L Marisa, C Loncle, O Gayet… - Cell reports, 2017 - cell.com
Preclinical models based on patient-derived xenografts have remarkable specificity in
distinguishing transformed human tumor cells from non-transformed murine stromal cells …

[HTML][HTML] Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications

Y Blum, C Meiller, L Quetel, N Elarouci, M Ayadi… - Nature …, 2019 - nature.com
Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both on
histology and molecular profiling. Histology addresses inter-tumor and intra-tumor …

[HTML][HTML] Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

R Nicolle, Y Blum, P Duconseil, C Vanbrugghe… - …, 2020 - thelancet.com
Background A significant gap in pancreatic ductal adenocarcinoma (PDAC) patient's care is
the lack of molecular parameters characterizing tumours and allowing a personalized …

[HTML][HTML] Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression

R Nicolle, M Ayadi, A Gomez-Brouchet… - Nature …, 2019 - nature.com
Chondrosarcomas are primary cancers of cartilaginous tissue with highly contrasting
prognoses. These tumors are defined by recurrent mutations in the IDH genes and other …

[HTML][HTML] Investigation of radiosensitivity gene signatures in cancer cell lines

JS Hall, R Iype, J Senra, J Taylor, L Armenoult… - PloS one, 2014 - journals.plos.org
Intrinsic radiosensitivity is an important factor underlying radiotherapy response, but there is
no method for its routine assessment in human tumours. Gene signatures are currently …

[HTML][HTML] Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer

R Cohen, V Jonchère… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Metastatic colorectal cancers (mCRC) harboring microsatellite instability (MSI) are sensitive
to immune checkpoint inhibitors (ICIs), but the mechanisms of resistance to ICIs remain …

[HTML][HTML] Identification of positively and negatively selected driver gene mutations associated with colorectal cancer with microsatellite instability

V Jonchère, L Marisa, M Greene, A Virouleau… - Cellular and molecular …, 2018 - Elsevier
Background & Aims Recent studies have shown that cancers arise as a result of the positive
selection of driver somatic events in tumor DNA, with negative selection playing only a minor …

Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity

JS Hall, R Iype, LSC Armenoult, J Taylor… - International Journal of …, 2013 - Elsevier
PURPOSE: To investigate the relationship between human papillomavirus (HPV) genotype
and outcome after radiation therapy and intrinsic radiosensitivity. METHODS AND …

[HTML][HTML] DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification

C Decamps, A Arnaud, F Petitprez, M Ayadi… - BMC …, 2021 - Springer
Background Quantification of tumor heterogeneity is essential to better understand cancer
progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to …