Cell cycle progression and division is regulated by checkpoint controls and sequential
activation of cyclin-dependent kinases (CDKs). Understanding of how these events occur in …

Current mortality due to the Covid-19 pandemic (approximately 1.2 million by November
2020) demonstrates the lack of an effective treatment. As replication of many viruses …

ACLY links energy metabolism provided by catabolic pathways to biosynthesis. ACLY,
which has been found to be overexpressed in many cancers, converts citrate into acetyl-CoA …

The number of clinical protocols testing combined therapies including immune check-point
inhibitors and platinum salts is currently increasing in lung cancer treatment, however …

Simple Summary In resected lung cancer, adjuvant and neoadjuvant chemotherapy
following surgery are currently mainly based on TNM classification. With the validation and …

Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through
their cytotoxic effector functions and their capacity to interact with other immune cells to build …

NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer
therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) have a higher
prevalence of lung cancer. The chronic inflammation associated with COPD probably …

OBJECTIVES The twin aims of this study were to identify the independent predictors of 30-
day mortality and to analyse the outcomes of patients with cardiogenic shock (CS) …