The broad use of radiotherapy (RT) in the management of solid human tumors is based on
its ability to damage cellular macromolecules, particularly the DNA, effectively inducing …

Tumor microenvironment (TME) is the local environment of tumor, composed of tumor cells
and blood vessels, extracellular matrix (ECM), immune cells, and metabolic and signaling …

Circulating tumor cells (CTCs) have emerged as a viable solution to the lack of tumor tissue
availability for patients with a variety of solid tumors, including prostate cancer. Different …

Prostate cancer growth depends on androgen receptor signaling. Androgen ablation
therapy induces expression of constitutively active androgen receptor splice variants that …

Purpose: Biomarkers aiding treatment optimization in metastatic castration-resistant prostate
cancer (mCRPC) are scarce. The presence or absence of androgen receptor (AR) splice …

The CXCR4/CXCL12 axis plays a role in cancer metastases, stem cell mobilization and
chemosensitization. Proof of concept for efficient CXCR4 inhibition has been demonstrated …

Results Sixty-three patients were randomly assigned to docetaxel (n= 41) or cabazitaxel (n=
22); 44.4% received prior potent androgen receptor–targeted therapy. Overall, 35 patients …

Background Inefficient T-cell access to the tumor microenvironment (TME) is among the
causes of tumor immune-resistance. Previous evidence demonstrated that targeting CXCR4 …

Background Colorectal cancer (CRC) is one of the most prevalent and deadly tumors
worldwide. The majority of CRC is resistant to anti-programmed cell death-1 (PD-1)-based …

Objective To identify a phenotype that could be informative and prognostic in patients with
renal cell carcinoma (RCC) peripheral blood was evaluated for TH 1, TH 2, regulatory T cells …