Multivalent antibodies: when design surpasses evolution

ÁM Cuesta, N Sainz-Pastor, J Bonet, B Oliva… - Trends in …, 2010 - cell.com
Evolutionary pressure has selected antibodies as key immune molecules acting against
foreign pathogens. The development of monoclonal antibody technology has allowed their …

[HTML][HTML] Bi-and trispecific immune cell engagers for immunotherapy of hematological malignancies

A Tapia-Galisteo, L Álvarez-Vallina, L Sanz - Journal of Hematology & …, 2023 - Springer
Immune cell engagers are engineered antibodies with at least one arm binding a tumor-
associated antigen and at least another one directed against an activating receptor in …

[HTML][HTML] When three is not a crowd: trispecific antibodies for enhanced cancer immunotherapy

A Tapia-Galisteo, M Compte, L Álvarez-Vallina… - Theranostics, 2023 - ncbi.nlm.nih.gov
Despite the clinical success of the first bispecific antibody approved by the FDA against B
cell malignancies (blinatumomab), many obstacles remain such as dosing, treatment …

[HTML][HTML] Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes

I Guijarro-Muñoz, M Compte… - Journal of Biological …, 2014 - ASBMB
Pericytes and mesenchymal stem cells (MSCs) are ontogenically related, and in fact, no
significant phenotypic differences could be observed by flow cytometry. Transcriptome …

Programming Controlled Adhesion of E. coli to Target Surfaces, Cells, and Tumors with Synthetic Adhesins

C Piñero-Lambea, G Bodelón… - ACS synthetic …, 2015 - ACS Publications
In this work we report synthetic adhesins (SAs) enabling the rational design of the adhesion
properties of E. coli. SAs have a modular structure comprising a stable β-domain for outer …

Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds

M Compte, ÁM Cuesta, D Sánchez-Martín… - Stem …, 2009 - academic.oup.com
Mesenchymal stem cells (MSCs) are appealing as gene therapy cell vehicles given their
ease of expansion and transduction. However, MSCs exhibit immunomodulatory and …

A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response

L Rubio-Pérez, R Lázaro-Gorines, SL Harwood… - …, 2023 - Taylor & Francis
Immune checkpoint blockade (ICB) with antibodies has shown durable clinical responses in
a wide range of cancer types, but the overall response rate is still limited. Other effective …

Long-term in vivo imaging of human angiogenesis: critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels

L Sanz, P Santos-Valle, V Alonso-Camino, C Salas… - Microvascular …, 2008 - Elsevier
Angiogenesis is a multistep process that encompasses complex molecular and cellular
interactions that can not be recapitulated in vitro. Here, we demonstrate that vasculature …

Antibody engineering: facing new challenges in cancer therapy1

L Sanz, ÁM Cuesta, M Compte… - Acta …, 2005 - Wiley Online Library
Antibody‐based therapeutics are beginning to realize the promise enclosed in their early
denomination as “magic bullets”. Initial disappointment has turned into clinical and …

[HTML][HTML] Understanding the spatial topology of artificial immunological synapses assembled in T cell-redirecting strategies: a major issue in cancer immunotherapy

P Roda-Navarro, L Álvarez-Vallina - Frontiers in cell and …, 2020 - frontiersin.org
T cell-redirection strategies aim to selectively eliminate cancer cells by physically linking T
lymphocytes with cancer cells using tumor-targeted cell-cell bridging (CCB) molecules, such …