Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common
theme in human cancers. In addition to polypeptide growth factors such as EGF family …

Purpose: Patients with anaplastic lymphoma kinase (ALK) gene rearrangements often
manifest dramatic responses to crizotinib, a small-molecule ALK inhibitor. Unfortunately, not …

In our previous study we showed that insulin-like growth factor-I induces a cAMP-response
element (CRE) site-containing Bcl-2 promoter through a novel signaling pathway involving …

The literature provides strong precedent for both protumorigenic and tumor suppressor roles
for the c-Jun N-terminal kinases (JNKs) in the setting of oncogenesis. Clearly, JNKs are …

I. Introduction THE family of heterotrimeric G proteins, referred to as G proteins, functions by
coupling specific cell surface receptors to the control of intracellular signal transduction …

Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and
EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase …

Non-small cell lung cancer (NSCLC) is a prevalent and devastating disease that claims
more lives than breast, prostate, colon and pancreatic cancers combined. Current research …

Non-small cell lung cancer (NSCLC) cells have constitutively high expression of cytosolic
phospholipase A2 (cPLA2) and cyclooxygenase (COX) 2. These NSCLC cells also have …

Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs,
nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell …

The Wnt signaling pathway is critical in normal development, and mutation of specific
components is frequently observed in carcinomas of diverse origins. However, the potential …