[PDF][PDF] Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver

M Monetti, MC Levin, MJ Watt, MP Sajan, S Marmor… - Cell metabolism, 2007 - cell.com
Hepatic steatosis, the accumulation of lipids in the liver, is widely believed to result in insulin
resistance. To test the causal relationship between hepatic steatosis and insulin resistance …

[HTML][HTML] The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its …

SJ Stone, MC Levin, P Zhou, J Han, TC Walther… - Journal of Biological …, 2009 - ASBMB
The synthesis and storage of neutral lipids in lipid droplets is a fundamental property of
eukaryotic cells, but the spatial organization of this process is poorly understood. Here we …

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

C Pirazzi, L Valenti, BM Motta, P Pingitore… - Human molecular …, 2014 - academic.oup.com
Retinoids are micronutrients that are stored as retinyl esters in the retina and hepatic stellate
cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme …

[HTML][HTML] The myocardium-protective Gly-49 variant of the β1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation

MC Levin, S Marullo, O Muntaner, B Andersson… - Journal of Biological …, 2002 - ASBMB
The β 1-adrenergic receptor (β 1 AR) is a major mediator of catecholamine effects in human
heart. Patients with heart failure who were hetero-or homozygous for the Gly-49 variant of …

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro

C Pirazzi, M Adiels, MA Burza, RM Mancina… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: The robust association between non-alcoholic fatty liver disease
(NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated …

[HTML][HTML] Membrane topology and identification of key functional amino acid residues of murine acyl-CoA: diacylglycerol acyltransferase-2

SJ Stone, MC Levin, RV Farese - Journal of Biological Chemistry, 2006 - ASBMB
Triacylglycerols are the predominant molecules of energy storage in eukaryotes. However,
excessive accumulation of triacylglycerols in adipose tissue leads to obesity and, in …

Triglyceride containing lipid droplets and lipid droplet-associated proteins

SO Olofsson, P Boström, L Andersson… - Current opinion in …, 2008 - journals.lww.com
Recent studies have identified a number of key proteins that are involved in the formation
and turnover of lipid droplets, and SNAP23 has been identified as a link between …

ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan

A Hiukka, M Ståhlman, C Pettersson, M Levin… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Apolipoprotein CIII (apoCIII) is an independent risk factor for cardiovascular
disease, but the molecular mechanisms involved are poorly understood. We investigated …

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle

MC Levin, M Monetti, MJ Watt… - American Journal …, 2007 - journals.physiology.org
Insulin resistance and type 2 diabetes are frequently accompanied by lipid accumulation in
skeletal muscle. However, it is unknown whether primary lipid deposition in skeletal muscle …

Ser49Gly of β1‐adrenergic receptor is associated with effective β‐blocker dose in dilated cardiomyopathy

Y Magnusson, MC Levin, R Eggertsen… - Clinical …, 2005 - Wiley Online Library
Objective Our objective was to evaluate the influence of polymorphisms at codons 49 and
389 of the β1‐adrenergic receptor (β1‐AR) on the response to β‐blockers and outcome in …