User profiles for "author:Marc Remke"

Marc Remke

German Cancer Research Center / German Cancer Consortium / University Hospital …
Verified email at med.uni-duesseldorf.de
Cited by 26544

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

V Ramaswamy, M Remke, E Bouffet, S Bailey… - Acta …, 2016 - Springer
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …

[HTML][HTML] Molecular subgroups of medulloblastoma: the current consensus

MD Taylor, PA Northcott, A Korshunov, M Remke… - Acta …, 2012 - Springer
Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of
morbidity and mortality in pediatric oncology. Current mechanisms for clinical …

[HTML][HTML] Dissecting the genomic complexity underlying medulloblastoma

DTW Jones, N Jäger, M Kool, T Zichner, B Hutter… - Nature, 2012 - nature.com
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or
medulla/brain stem. It is the most common malignant brain tumour in children, and shows …

[HTML][HTML] Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

T Rausch, DTW Jones, M Zapatka, AM Stütz, T Zichner… - Cell, 2012 - cell.com
Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive …

[PDF][PDF] Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

M Kool, DTW Jones, N Jäger, PA Northcott, TJ Pugh… - Cancer cell, 2014 - cell.com
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the …

[HTML][HTML] Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and …

M Kool, A Korshunov, M Remke, DTW Jones… - Acta …, 2012 - Springer
Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies
from several groups around the world demonstrated that medulloblastoma is not one …

[PDF][PDF] Intertumoral heterogeneity within medulloblastoma subgroups

FMG Cavalli, M Remke, L Rampasek, J Peacock… - Cancer cell, 2017 - cell.com
While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

[HTML][HTML] Subgroup-specific structural variation across 1,000 medulloblastoma genomes

PA Northcott, DJH Shih, J Peacock, L Garzia… - Nature, 2012 - nature.com
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

PA Northcott, C Lee, T Zichner, AM Stütz, S Erkek… - Nature, 2014 - nature.com
Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of …

[PDF][PDF] New brain tumor entities emerge from molecular classification of CNS-PNETs

D Sturm, BA Orr, UH Toprak, V Hovestadt, DTW Jones… - Cell, 2016 - cell.com
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …