User profiles for "author:Marc Remke"
Marc RemkeGerman Cancer Research Center / German Cancer Consortium / University Hospital … Verified email at med.uni-duesseldorf.de Cited by 26544 |
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …
variables pertaining to age, presence of metastases, extent of resection, histological …
[HTML][HTML] Molecular subgroups of medulloblastoma: the current consensus
Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of
morbidity and mortality in pediatric oncology. Current mechanisms for clinical …
morbidity and mortality in pediatric oncology. Current mechanisms for clinical …
[HTML][HTML] Dissecting the genomic complexity underlying medulloblastoma
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or
medulla/brain stem. It is the most common malignant brain tumour in children, and shows …
medulla/brain stem. It is the most common malignant brain tumour in children, and shows …
[HTML][HTML] Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive …
Recent findings, however, suggest an alternative mechanism, involving massive …
[PDF][PDF] Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the …
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the …
[HTML][HTML] Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and …
Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies
from several groups around the world demonstrated that medulloblastoma is not one …
from several groups around the world demonstrated that medulloblastoma is not one …
[PDF][PDF] Intertumoral heterogeneity within medulloblastoma subgroups
While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
[HTML][HTML] Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of …
combination of surgery, radiation and chemotherapy, posing a considerable burden of …
[PDF][PDF] New brain tumor entities emerge from molecular classification of CNS-PNETs
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …