Background The suppressive nature of immune cells in the tumor microenvironment plays a
major role in regulating anti-tumor immune responses. Our previous work demonstrated that …

Renal cell carcinoma (RCC) is the most common type of kidney cancer and comprises
several subtypes with unique characteristics. The most common subtype (~ 70% of cases) is …

Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature
myeloid cells endowed with suppressive function on the immune response. Their presence …

Immune evasion is a hallmark of cancer. While there are multiple different mechanisms that
cancer cells employ, myeloid-derived suppressor cells (MDSCs) are one of the key drivers of …

Abnormal accumulation of myeloid-derived suppressor cells (MDSC) is an important
mechanism of tumor immune evasion. Cyclophosphamide (CTX) has also been shown in …

We recently demonstrated that human BM cells can be treated in vitro with defined growth
factors to induce the rapid generation of myeloid-derived suppressor cells (MDSCs) …

Purpose: Little is known about the association between myeloid-derived suppressor cell
(MDSC) subsets and various chemokines in patients with renal cell carcinoma (RCC) or the …

Background Cancer immunotherapy is associated with several immune-related adverse
events, but the relationship between immunotherapy and venous thromboembolism has not …

Immune checkpoint inhibitor (ICI) therapy continues to revolutionize melanoma treatment,
but only a subset of patients respond. Major efforts are underway to develop minimally …

Abstract Background Talimogene Laherparepvec (T-VEC) is an oncolytic virus approved as
an intratumoral therapy for treating unresectable stage IIIB-IV metastatic melanoma. The …