[HTML][HTML] Skin cancer classification via convolutional neural networks: systematic review of studies involving human experts

S Haggenmüller, RC Maron, A Hekler, JS Utikal… - European Journal of …, 2021 - Elsevier
Background Multiple studies have compared the performance of artificial intelligence (AI)–
based models for automated skin cancer classification to human experts, thus setting the …

[HTML][HTML] Explainable artificial intelligence in skin cancer recognition: A systematic review

K Hauser, A Kurz, S Haggenmüller, RC Maron… - European Journal of …, 2022 - Elsevier
Background Due to their ability to solve complex problems, deep neural networks (DNNs)
are becoming increasingly popular in medical applications. However, decision-making by …

Immune checkpoint blockade for unresectable or metastatic uveal melanoma: A systematic review

MV Heppt, T Steeb, JG Schlager, S Rosumeck… - Cancer treatment …, 2017 - Elsevier
Background The use of immune checkpoint blockade (ICB) for uveal melanoma (UM) is little
established. The aim of this review was to provide a comprehensive overview on the …

[HTML][HTML] Deep learning outperformed 136 of 157 dermatologists in a head-to-head dermoscopic melanoma image classification task

TJ Brinker, A Hekler, AH Enk, J Klode… - European Journal of …, 2019 - Elsevier
Background Recent studies have successfully demonstrated the use of deep-learning
algorithms for dermatologist-level classification of suspicious lesions by the use of excessive …

[HTML][HTML] A convolutional neural network trained with dermoscopic images performed on par with 145 dermatologists in a clinical melanoma image classification task

TJ Brinker, A Hekler, AH Enk, J Klode… - European Journal of …, 2019 - Elsevier
Background Recent studies have demonstrated the use of convolutional neural networks
(CNNs) to classify images of melanoma with accuracies comparable to those achieved by …

[HTML][HTML] Myositis and neuromuscular side-effects induced by immune checkpoint inhibitors

A Moreira, C Loquai, C Pföhler, KC Kähler… - European Journal of …, 2019 - Elsevier
Aim To characterise clinical presentation, laboratory and histopathologic characteristics and
assess the treatment and outcome of neuromuscular side-effects of checkpoint therapy …

[HTML][HTML] Prognostic factors and outcomes in metastatic uveal melanoma treated with programmed cell death-1 or combined PD-1/cytotoxic T-lymphocyte antigen-4 …

MV Heppt, L Heinzerling, KC Kähler… - European Journal of …, 2017 - Elsevier
Background Uveal melanoma (UM) is an ocular malignancy with high potential for
metastatic spread. In contrast to cutaneous melanoma, immunotherapy has not yet shown …

[HTML][HTML] Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care

MV Heppt, T Siepmann, J Engel, G Schubert-Fritschle… - BMC cancer, 2017 - Springer
Background Hotspot mutations of the oncogenes BRAF and NRAS are the most common
genetic alterations in cutaneous melanoma. Specific inhibitors of BRAF and MEK have …

[HTML][HTML] Combining CNN-based histologic whole slide image analysis and patient data to improve skin cancer classification

J Höhn, E Krieghoff-Henning, TB Jutzi… - European Journal of …, 2021 - Elsevier
Background Clinicians and pathologists traditionally use patient data in addition to clinical
examination to support their diagnoses. Objectives We investigated whether a combination …

[HTML][HTML] IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression

A Thiem, S Hesbacher, H Kneitz, T di Primio… - Journal of Experimental …, 2019 - Springer
Background Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have
revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 …