User profiles for "author:Martin Böttcher"

Martin Böttcher

Universitätsklinikum Magdeburg
Verified email at med.ovgu.de
Cited by 3196

[HTML][HTML] Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

S Lucas, Y Omata, J Hofmann, M Böttcher… - Nature …, 2018 - nature.com
Microbial metabolites are known to modulate immune responses of the host. The main
metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain …

[PDF][PDF] The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

J Friščić, M Böttcher, C Reinwald, H Bruns, B Wirth… - Immunity, 2021 - cell.com
Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

[PDF][PDF] IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

M Faas, N Ipseiz, J Ackermann, S Culemann… - Immunity, 2021 - cell.com
Alternatively activated macrophages (AAMs) contribute to the resolution of inflammation and
tissue repair. However, molecular pathways that govern their differentiation have remained …

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress

D Mougiakakos, CC Johansson… - Blood, The Journal …, 2011 - ashpublications.org
Levels of regulatory T cells (Tregs) are increased in different cancer types as well as in
inflammatory diseases, such as rheumatoid arthritis. Treg accumulation may result from …

[PDF][PDF] β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression

D Hofbauer, D Mougiakakos, L Broggini, M Zaiss… - Immunity, 2021 - cell.com
As substantial constituents of the multiple myeloma (MM) microenvironment, pro-
inflammatory macrophages have emerged as key promoters of disease progression, bone …

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction

C Wehmeyer, S Frank, D Beckmann… - Science translational …, 2016 - science.org
Sclerostin, an inhibitor of the Wnt/β-catenin pathway, has anti-anabolic effects on bone
formation by negatively regulating osteoblast differentiation. Mutations in the human …

Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3

J Boy, T Schmidt, H Wolburg, A Mack… - Human molecular …, 2009 - academic.oup.com
Abstract Spinocerebellar ataxia type 3 (SCA3) is caused by the expansion of a CAG repeat
tract that affects the MJD1 gene which encodes the ataxin-3 protein. In order to analyze …

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

M Böttcher, K Renner, R Berger, K Mentz… - …, 2018 - Taylor & Francis
ABSTRACT D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells
including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain …

Providing a method for composing modular B2B services

M Böttcher, S Klingner - Journal of Business & Industrial Marketing, 2011 - emerald.com
Purpose–The purpose of this paper is to provide a method that allows the decollating of
formerly monolithic services into separate modules. To provide a semantically equivalent …

Polyol pathway links glucose metabolism to the aggressiveness of cancer cells

A Schwab, A Siddiqui, ME Vazakidou, F Napoli… - Cancer research, 2018 - AACR
Cancer cells alter their metabolism to support their malignant properties. In this study, we
report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1 …