Background Patients who have had a stroke with unknown time of onset have been
previously excluded from thrombolysis. We aimed to establish whether intravenous …

Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However,
DNA copy number and gene expression signatures indicate differences between adult and …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays
considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting …

We sought to determine if an association exists between overall, deep, and periventricular
white matter hyperintensities and depression. We searched PubMed (Medline) and Scopus …

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or
medulla/brain stem. It is the most common malignant brain tumour in children, and shows …

Importance So far, uncertainty remains as to whether there is sufficient cumulative evidence
that mobile stroke unit (MSU; specialized ambulance equipped with computed tomography …

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with
mitogen-activated protein kinase (MAPK) pathway alterations. Surgically inaccessible …

Background Under current guidelines, intravenous thrombolysis is used to treat acute stroke
only if it can be ascertained that the time since the onset of symptoms was less than 4.5 …