Cell migration is a highly integrated multistep process that orchestrates embryonic
morphogenesis; contributes to tissue repair and regeneration; and drives disease …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Integrins receive signals from other receptors that lead to activation of ligand binding (inside-
out signaling) and matrix assembly. Upon binding ligands, they also activate intracellular …

Shear stress is a fundamental determinant of vascular homeostasis, regulating vascular
remodelling, cardiac development and atherogenesis, but the mechanisms of transduction …

Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the
small GTP-binding protein Rho based on their ability to induce actin stress fibers and focal …

Mechanical forces are central to developmental, physiological and pathological processes.
However, limited understanding of force transmission within sub-cellular structures is a …

Forces that are associated with blood flow are major determinants of vascular
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …

Cellular responses to mechanical forces are crucial in embryonic development and adult
physiology, and are involved in numerous diseases, including atherosclerosis …

Multicellular organisms must coordinate signals from adhesion receptors with those from
other signalling receptors (for example, growth factor receptors). Here, we briefly review …