Gastric cancer, 1 of the 5 most common causes of cancer death, is associated with a 5-year
overall survival rate less than 30%. A minority of cancers occurs as part of syndromic …

Western countries are seeing a constant decline in the incidence of Helicobacter pylori-
associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune …

Liver cancer represents the third leading cause of cancer-related death worldwide.
Cholangiocarcinoma (CCA) is the second most common type of liver cancer after …

Patient-derived organoids (PDOs) have recently emerged as robust preclinical models;
however, their potential to predict clinical outcomes in patients has remained unclear. We …

The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

OBJECTIVES: Micro-RNAs are a group of small noncoding RNAs with modulator activity of
gene expression. Recently, micro-RNA genes were found abnormally expressed in several …

Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered
frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1 …

Small non‐coding microRNAs (miRNAs) contribute to cancer development and progression,
and are differentially expressed in normal tissues and cancers. However, the specific role of …

Importance Mismatch repair (MMR) deficiency (MMRD) and microsatellite instability (MSI)
are prognostic for survival in many cancers and for resistance to fluoropyrimidines in early …

Ageing is intimately connected to the induction of cell senescence,, but why this is so
remains poorly understood. A key challenge is the identification of pathways that normally …