Background and aim Thymus-derived regulatory T cells (Tregs) mediate dominant
peripheral tolerance and treat experimental colitis. Tregs can be expanded from patient …

The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition
but is commensurate with significant immune-related adverse events suboptimally limiting …

Background Immune checkpoint blockade (ICB) promotes adaptive immunity and tumor
regression in some cancer patients. However, in patients with immunologically “cold” …

Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1, 3 glucans, and its
stimulation initiates signaling events characterized by the production of inflammatory …

The innate immune system is a critical component of host defence against microbial
pathogens, but effective responses require an ability to distinguish between infectious and …

Oncolytic virus (OV) therapy is an emerging approach with the potential to redefine treatment
options across a range of cancer indications and in patients who remain resistant to existing …

Thymic stromal lymphopoietin (TSLP) produced by epithelial cells acts on dendritic cells
(DCs) to drive differentiation of TH2‐cells, and is therefore important in allergic disease …

Protein kinase RNA activated (PKR) is a crucial mediator of anti-viral responses but is
reported to be activated by multiple non-viral stimuli. However, mechanisms underlying PKR …

Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in
immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is …

Introduction Humanized mice are emerging as valuable models to experimentally evaluate
the impact of different immunotherapeutics on the human immune system. These …