Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression
L Vanhersecke, M Brunet, JP Guégan, C Rey… - Nature Cancer, 2021 - nature.com
Only a minority of patients derive long-term clinical benefit from anti-programmed cell death
protein 1 (anti-PD-1) or anti-programmed death-ligand 1 (anti-PD-L1) monoclonal …
protein 1 (anti-PD-1) or anti-programmed death-ligand 1 (anti-PD-L1) monoclonal …
Quantitative experimental observation of weak inertial-wave turbulence
We report the quantitative experimental observation of the weak inertial-wave turbulence
regime of rotating turbulence. We produce a statistically steady homogeneous turbulent flow …
regime of rotating turbulence. We produce a statistically steady homogeneous turbulent flow …
Standardized pathology screening of mature tertiary lymphoid structures in cancers
L Vanhersecke, A Bougouin, A Crombé, M Brunet… - Laboratory …, 2023 - Elsevier
Mature tertiary lymphoid structures (mTLSs) are organized lymphoid structures containing B
lymphocytes admixed to CD23+ follicular dendritic cells. Their presence has been linked to …
lymphocytes admixed to CD23+ follicular dendritic cells. Their presence has been linked to …
[HTML][HTML] Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies
M Larroquette, JP Guegan, B Besse… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Background Tumor-associated macrophages (TAMs) having immunosuppressive properties
are one of the most abundant immune cells in the tumor microenvironment (TME) …
are one of the most abundant immune cells in the tumor microenvironment (TME) …
[HTML][HTML] Enabling precision medicine for rare head and neck tumors: the example of BRAF/MEK targeting in patients with metastatic ameloblastoma
M Brunet, E Khalifa, A Italiano - Frontiers in Oncology, 2019 - frontiersin.org
Background: Ameloblastoma is a rare head and neck tumor characterized by a high
incidence of BRAF mutation providing a rationale for the use of BRAF inhibitors in patients …
incidence of BRAF mutation providing a rationale for the use of BRAF inhibitors in patients …
Shortcut to geostrophy in wave-driven rotating turbulence: the quartetic instability
We report on laboratory experiments of wave-driven rotating turbulence. A set of wave
makers produces inertial-wave beams that interact nonlinearly in the central region of a …
makers produces inertial-wave beams that interact nonlinearly in the central region of a …
Three-dimensionality of the triadic resonance instability of a plane inertial wave
We analyze theoretically and experimentally the triadic resonance instability (TRI) of a plane
inertial wave in a rotating fluid. Building on the classical triadic interaction equations …
inertial wave in a rotating fluid. Building on the classical triadic interaction equations …
Linear and nonlinear regimes of an inertial wave attractor
We present an experimental analysis of the linear and nonlinear regimes of an attractor of
inertial waves in a trapezoidal cavity under rotation. Varying the rotation rate and the forcing …
inertial waves in a trapezoidal cavity under rotation. Varying the rotation rate and the forcing …
Fast replanning of a lower-limb exoskeleton trajectories for rehabilitation
M Brunet, M Pétriaux, F Di Meglio… - 2022 IEEE 61st …, 2022 - ieeexplore.ieee.org
The paper addresses the rehabilitation of disabled patients using a lower-limb fully-actuated
exoskeleton. We propose a novel numerical method to replan the current step without …
exoskeleton. We propose a novel numerical method to replan the current step without …
Enabling safe walking rehabilitation on the exoskeleton Atalante: experimental results
M Brunet, M Pétriaux, F Di Meglio… - 2023 IEEE International …, 2023 - ieeexplore.ieee.org
This paper exposes a control architecture enabling rehabilitation of walking impaired
patients with the lower-limb exoskeleton Atalante. Atalante's control system is modified to …
patients with the lower-limb exoskeleton Atalante. Atalante's control system is modified to …