Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression

L Vanhersecke, M Brunet, JP Guégan, C Rey… - Nature Cancer, 2021 - nature.com
Only a minority of patients derive long-term clinical benefit from anti-programmed cell death
protein 1 (anti-PD-1) or anti-programmed death-ligand 1 (anti-PD-L1) monoclonal …

Quantitative experimental observation of weak inertial-wave turbulence

E Monsalve, M Brunet, B Gallet, PP Cortet - Physical Review Letters, 2020 - APS
We report the quantitative experimental observation of the weak inertial-wave turbulence
regime of rotating turbulence. We produce a statistically steady homogeneous turbulent flow …

Standardized pathology screening of mature tertiary lymphoid structures in cancers

L Vanhersecke, A Bougouin, A Crombé, M Brunet… - Laboratory …, 2023 - Elsevier
Mature tertiary lymphoid structures (mTLSs) are organized lymphoid structures containing B
lymphocytes admixed to CD23+ follicular dendritic cells. Their presence has been linked to …

[HTML][HTML] Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies

M Larroquette, JP Guegan, B Besse… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Background Tumor-associated macrophages (TAMs) having immunosuppressive properties
are one of the most abundant immune cells in the tumor microenvironment (TME) …

[HTML][HTML] Enabling precision medicine for rare head and neck tumors: the example of BRAF/MEK targeting in patients with metastatic ameloblastoma

M Brunet, E Khalifa, A Italiano - Frontiers in Oncology, 2019 - frontiersin.org
Background: Ameloblastoma is a rare head and neck tumor characterized by a high
incidence of BRAF mutation providing a rationale for the use of BRAF inhibitors in patients …

Shortcut to geostrophy in wave-driven rotating turbulence: the quartetic instability

M Brunet, B Gallet, PP Cortet - Physical Review Letters, 2020 - APS
We report on laboratory experiments of wave-driven rotating turbulence. A set of wave
makers produces inertial-wave beams that interact nonlinearly in the central region of a …

Three-dimensionality of the triadic resonance instability of a plane inertial wave

DO Mora, E Monsalve, M Brunet, T Dauxois… - Physical Review Fluids, 2021 - APS
We analyze theoretically and experimentally the triadic resonance instability (TRI) of a plane
inertial wave in a rotating fluid. Building on the classical triadic interaction equations …

Linear and nonlinear regimes of an inertial wave attractor

M Brunet, T Dauxois, PP Cortet - Physical Review Fluids, 2019 - APS
We present an experimental analysis of the linear and nonlinear regimes of an attractor of
inertial waves in a trapezoidal cavity under rotation. Varying the rotation rate and the forcing …

Fast replanning of a lower-limb exoskeleton trajectories for rehabilitation

M Brunet, M Pétriaux, F Di Meglio… - 2022 IEEE 61st …, 2022 - ieeexplore.ieee.org
The paper addresses the rehabilitation of disabled patients using a lower-limb fully-actuated
exoskeleton. We propose a novel numerical method to replan the current step without …

Enabling safe walking rehabilitation on the exoskeleton Atalante: experimental results

M Brunet, M Pétriaux, F Di Meglio… - 2023 IEEE International …, 2023 - ieeexplore.ieee.org
This paper exposes a control architecture enabling rehabilitation of walking impaired
patients with the lower-limb exoskeleton Atalante. Atalante's control system is modified to …